tetano
Editor, Senior Moderator
Commun Biol
. 2023 Sep 13;6(1):935.
doi: 10.1038/s42003-023-05263-6. Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice
Zaigham Abbas Rizvi[SUP] 1 2 [/SUP], Jyotsna Dandotiya[SUP] 3 [/SUP], Srikanth Sadhu[SUP] 3 4 [/SUP], Ritika Khatri[SUP] 5 [/SUP], Janmejay Singh[SUP] 6 [/SUP], Virendra Singh[SUP] 3 4 [/SUP], Neeta Adhikari[SUP] 3 [/SUP], Kritika Sharma[SUP] 3 4 [/SUP], Vinayake Das[SUP] 3 4 [/SUP], Amit Kumar Pandey[SUP] 7 [/SUP], Bhabatosh Das[SUP] 8 [/SUP], Guruprasad Medigeshi[SUP] 6 [/SUP], Shalendra Mani[SUP] 5 [/SUP], Shinjini Bhatnagar[SUP] 9 [/SUP], Sweety Samal[SUP] 5 [/SUP], Anil Kumar Pandey[SUP] 10 [/SUP], Pramod Kumar Garg[SUP] 11 [/SUP], Amit Awasthi[SUP] 12 13 [/SUP]
Affiliations
A recently emerged sub-lineage of Omicron, BA.5, together with BA.4, caused a fifth wave of coronavirus disease (COVID-19) in South Africa and subsequently emerged as a predominant strain globally due to its high transmissibility. The lethality of BA.5 infection has not been studied in an acute hACE2 transgenic (hACE2.Tg) mouse model. Here, we investigated tissue-tropism and immuno-pathology induced by BA.5 infection in hACE2.Tg mice. Our data show that intranasal infection of BA.5 in hACE2.Tg mice resulted in attenuated pulmonary infection and pathology with diminished COVID-19-induced clinical and pathological manifestations. BA.5, similar to Omicron (B.1.1.529), infection led to attenuated production of inflammatory cytokines, anti-viral response and effector T cell response as compared to the ancestral strain of SARS-CoV-2, Wuhan-Hu-1. We show that mice recovered from B.1.1.529 infection showed robust protection against BA.5 infection associated with reduced lung viral load and pathology. Together, our data provide insights as to why BA.5 infection escapes previous SARS-CoV-2 exposure induced-T cell immunity but may result in milder immuno-pathology and alleviated chances of re-infectivity in Omicron-recovered individuals.
. 2023 Sep 13;6(1):935.
doi: 10.1038/s42003-023-05263-6. Omicron sub-lineage BA.5 infection results in attenuated pathology in hACE2 transgenic mice
Zaigham Abbas Rizvi[SUP] 1 2 [/SUP], Jyotsna Dandotiya[SUP] 3 [/SUP], Srikanth Sadhu[SUP] 3 4 [/SUP], Ritika Khatri[SUP] 5 [/SUP], Janmejay Singh[SUP] 6 [/SUP], Virendra Singh[SUP] 3 4 [/SUP], Neeta Adhikari[SUP] 3 [/SUP], Kritika Sharma[SUP] 3 4 [/SUP], Vinayake Das[SUP] 3 4 [/SUP], Amit Kumar Pandey[SUP] 7 [/SUP], Bhabatosh Das[SUP] 8 [/SUP], Guruprasad Medigeshi[SUP] 6 [/SUP], Shalendra Mani[SUP] 5 [/SUP], Shinjini Bhatnagar[SUP] 9 [/SUP], Sweety Samal[SUP] 5 [/SUP], Anil Kumar Pandey[SUP] 10 [/SUP], Pramod Kumar Garg[SUP] 11 [/SUP], Amit Awasthi[SUP] 12 13 [/SUP]
Affiliations
- PMID: 37704701
- DOI: 10.1038/s42003-023-05263-6
A recently emerged sub-lineage of Omicron, BA.5, together with BA.4, caused a fifth wave of coronavirus disease (COVID-19) in South Africa and subsequently emerged as a predominant strain globally due to its high transmissibility. The lethality of BA.5 infection has not been studied in an acute hACE2 transgenic (hACE2.Tg) mouse model. Here, we investigated tissue-tropism and immuno-pathology induced by BA.5 infection in hACE2.Tg mice. Our data show that intranasal infection of BA.5 in hACE2.Tg mice resulted in attenuated pulmonary infection and pathology with diminished COVID-19-induced clinical and pathological manifestations. BA.5, similar to Omicron (B.1.1.529), infection led to attenuated production of inflammatory cytokines, anti-viral response and effector T cell response as compared to the ancestral strain of SARS-CoV-2, Wuhan-Hu-1. We show that mice recovered from B.1.1.529 infection showed robust protection against BA.5 infection associated with reduced lung viral load and pathology. Together, our data provide insights as to why BA.5 infection escapes previous SARS-CoV-2 exposure induced-T cell immunity but may result in milder immuno-pathology and alleviated chances of re-infectivity in Omicron-recovered individuals.