Common feed fungal toxin impairs the immune response induced by porcine reproductive and respiratory syndrome virus (PRRSV) live attenuated vaccine

[Emily]

http://www.sciencedirect.com/science/article/pii/S0264410X15008701

Vaccine
Volume 33, Issue 32, 31 July 2015, Pages 3881?3886


[h=1]Deoxynivalenol (DON) naturally contaminated feed impairs the immune response induced by porcine reproductive and respiratory syndrome virus (PRRSV) live attenuated vaccine[/h]

• Christian Savard[SUP]a[/SUP],
• Carl A. Gagnon[SUP]a[/SUP],
• Younes Chorfi[SUP]b[/SUP][SUP], [/SUP][SUP], [/SUP]

[h=2]Highlights[/h] ?Deoxynivalenol (DON) is a common mycotoxin found in pig feed. ?PRRS is economically important for North American swine industry. ?MLV vaccine is widely used to control PRRS. ?DON-contaminated diet could inhibit vaccination efficiency of PRRSV MLV.

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[h=2]Abstract[/h] Cereal commodities are frequently contaminated with mycotoxins produced by the secondary metabolism of fungal infection. Among these contaminants, deoxynivalenol (DON), also known as vomitoxin, is the most prevalent type B trichothecene mycotoxin worldwide. Pigs are very sensitive to the toxic effects of DON and are frequently exposed to naturally contaminated feed..

[h=2]Keywords[/h]

• Pig;
• DON mycotoxin;
• PRRSV;
• Vaccination