tetano
Editor, Senior Moderator
CMAJ
. 2024 Jun 16;196(23):E779-E788.
doi: 10.1503/cmaj.230760. The response of Canada's clinical health research ecosystem to the COVID-19 pandemic
François Lamontagne[SUP] 1 [/SUP], Marie-Hélène Masse[SUP] 2 [/SUP], Christopher Yarnell[SUP] 2 [/SUP], Félix Camirand-Lemyre[SUP] 2 [/SUP], Simon Lévesque[SUP] 2 [/SUP], Marie-Pier Domingue[SUP] 2 [/SUP], Katie O'Hearn[SUP] 2 [/SUP], Irene Watpool[SUP] 2 [/SUP], Jennifer Hoogenes[SUP] 2 [/SUP], Sheila Sprague[SUP] 2 [/SUP], Julie Ménard[SUP] 2 [/SUP], Samuel Lemaire-Paquette[SUP] 2 [/SUP], Laurent Hébert-Dufresne[SUP] 2 [/SUP], Deborah Cook[SUP] 2 [/SUP], Paul Hébert[SUP] 2 [/SUP], Kathryn Rowan[SUP] 2 [/SUP], Nicole Yada[SUP] 2 [/SUP], Kusum Menon[SUP] 2 [/SUP], Robert Fowler[SUP] 2 [/SUP], Alison Fox-Robichaud[SUP] 2 [/SUP], Denis Boutin[SUP] 2 [/SUP], John Marshall[SUP] 2 [/SUP], Michelle E Kho[SUP] 2 [/SUP]; Canadian Clinical Research Network (CCRN), the Canadian Critical Care Trials Group (CCCTG) and Sepsis Canada
Affiliations
Background: The response of Canada's research community to the COVID-19 pandemic provides a unique opportunity to examine the country's clinical health research ecosystem. We sought to describe patterns of enrolment across Canadian Institutes of Health Research (CIHR)-funded studies on COVID-19.
Methods: We identified COVID-19 studies funded by the CIHR and that enrolled participants from Canadian acute care hospitals between January 2020 and April 2023. We collected information on study-and site-level variables from study leads, site investigators, and public domain sources. We described and evaluated factors associated with cumulative enrolment.
Results: We obtained information for 23 out of 26 (88%) eligible CIHR-funded studies (16 randomized controlled trials [RCTs] and 7 cohort studies). The 23 studies were managed by 12 Canadian and 3 international coordinating centres. Of 419 Canadian hospitals, 97 (23%) enrolled a total of 28 973 participants - 3876 in RCTs across 78 hospitals (median cumulative enrolment per hospital 30, interquartile range [IQR] 10-61), and 25 097 in cohort studies across 62 hospitals (median cumulative enrolment per hospital 158, IQR 6-348). Of 78 hospitals recruiting participants in RCTs, 13 (17%) enrolled 50% of all RCT participants, whereas 6 of 62 hospitals (9.7%) recruited 54% of participants in cohort studies.
Interpretation: A minority of Canadian hospitals enrolled the majority of participants in CIHR-funded studies on COVID-19. This analysis sheds light on the Canadian health research ecosystem and provides information for multiple key partners to consider ways to realize the full research potential of Canada's health systems.
. 2024 Jun 16;196(23):E779-E788.
doi: 10.1503/cmaj.230760. The response of Canada's clinical health research ecosystem to the COVID-19 pandemic
François Lamontagne[SUP] 1 [/SUP], Marie-Hélène Masse[SUP] 2 [/SUP], Christopher Yarnell[SUP] 2 [/SUP], Félix Camirand-Lemyre[SUP] 2 [/SUP], Simon Lévesque[SUP] 2 [/SUP], Marie-Pier Domingue[SUP] 2 [/SUP], Katie O'Hearn[SUP] 2 [/SUP], Irene Watpool[SUP] 2 [/SUP], Jennifer Hoogenes[SUP] 2 [/SUP], Sheila Sprague[SUP] 2 [/SUP], Julie Ménard[SUP] 2 [/SUP], Samuel Lemaire-Paquette[SUP] 2 [/SUP], Laurent Hébert-Dufresne[SUP] 2 [/SUP], Deborah Cook[SUP] 2 [/SUP], Paul Hébert[SUP] 2 [/SUP], Kathryn Rowan[SUP] 2 [/SUP], Nicole Yada[SUP] 2 [/SUP], Kusum Menon[SUP] 2 [/SUP], Robert Fowler[SUP] 2 [/SUP], Alison Fox-Robichaud[SUP] 2 [/SUP], Denis Boutin[SUP] 2 [/SUP], John Marshall[SUP] 2 [/SUP], Michelle E Kho[SUP] 2 [/SUP]; Canadian Clinical Research Network (CCRN), the Canadian Critical Care Trials Group (CCCTG) and Sepsis Canada
Affiliations
- PMID: 38885975
- DOI: 10.1503/cmaj.230760
Background: The response of Canada's research community to the COVID-19 pandemic provides a unique opportunity to examine the country's clinical health research ecosystem. We sought to describe patterns of enrolment across Canadian Institutes of Health Research (CIHR)-funded studies on COVID-19.
Methods: We identified COVID-19 studies funded by the CIHR and that enrolled participants from Canadian acute care hospitals between January 2020 and April 2023. We collected information on study-and site-level variables from study leads, site investigators, and public domain sources. We described and evaluated factors associated with cumulative enrolment.
Results: We obtained information for 23 out of 26 (88%) eligible CIHR-funded studies (16 randomized controlled trials [RCTs] and 7 cohort studies). The 23 studies were managed by 12 Canadian and 3 international coordinating centres. Of 419 Canadian hospitals, 97 (23%) enrolled a total of 28 973 participants - 3876 in RCTs across 78 hospitals (median cumulative enrolment per hospital 30, interquartile range [IQR] 10-61), and 25 097 in cohort studies across 62 hospitals (median cumulative enrolment per hospital 158, IQR 6-348). Of 78 hospitals recruiting participants in RCTs, 13 (17%) enrolled 50% of all RCT participants, whereas 6 of 62 hospitals (9.7%) recruited 54% of participants in cohort studies.
Interpretation: A minority of Canadian hospitals enrolled the majority of participants in CIHR-funded studies on COVID-19. This analysis sheds light on the Canadian health research ecosystem and provides information for multiple key partners to consider ways to realize the full research potential of Canada's health systems.