tetano
Editor, Senior Moderator
Eur J Pediatr. 2010 Jul 22. [Epub ahead of print]
Clinical features of hospitalised children with 2009 H1N1 influenza virus infection.
Calitri C, Gabiano C, Garazzino S, Pinon M, Zoppo M, Cuozzo M, Scolfaro C, Tovo PA.
Department of Paediatrics, University of Turin, Regina Margherita Children's Hospital, Piazza Polonia 94, 10126, Turin, Italy, carmelina_calitri@libero.it.
Abstract
Clinical features and outcome of 2009 H1N1 influenza virus in the paediatric setting is ill-defined. The epidemiologic and clinical features of children with confirmed H1N1 influenza virus infection admitted to an Italian tertiary paediatric hospital from August through December 2009 were evaluated. A total of 63 children (mean age 4.3 years) were studied; of these, 29 (46%) had chronic underlying diseases. The most frequent symptoms and signs at admission were fever (97%), cough (60%) and respiratory disturbances (24%). Forty patients (63.5%) had H1N1-related complications: 32 (51%) pulmonary diseases, three (5%) neurological disorders, such as acute encephalitis or acute disseminated encephalomyelitis, and two (3%) haematological alterations. Three patients were admitted to the Intensive Care Unit. Most children (81%) were treated with oseltamivir: one developed rash during treatment; no other adverse events were noticed. All children survived without sequelae. In conclusions, 2009 H1N1 influenza virus infection in children is associated with a wide spectrum of clinical manifestations. Neurological disorders are not exceptional complications. Oseltamivir therapy seems safe also in infants.
PMID: 20652313 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20652313
Clinical features of hospitalised children with 2009 H1N1 influenza virus infection.
Calitri C, Gabiano C, Garazzino S, Pinon M, Zoppo M, Cuozzo M, Scolfaro C, Tovo PA.
Department of Paediatrics, University of Turin, Regina Margherita Children's Hospital, Piazza Polonia 94, 10126, Turin, Italy, carmelina_calitri@libero.it.
Abstract
Clinical features and outcome of 2009 H1N1 influenza virus in the paediatric setting is ill-defined. The epidemiologic and clinical features of children with confirmed H1N1 influenza virus infection admitted to an Italian tertiary paediatric hospital from August through December 2009 were evaluated. A total of 63 children (mean age 4.3 years) were studied; of these, 29 (46%) had chronic underlying diseases. The most frequent symptoms and signs at admission were fever (97%), cough (60%) and respiratory disturbances (24%). Forty patients (63.5%) had H1N1-related complications: 32 (51%) pulmonary diseases, three (5%) neurological disorders, such as acute encephalitis or acute disseminated encephalomyelitis, and two (3%) haematological alterations. Three patients were admitted to the Intensive Care Unit. Most children (81%) were treated with oseltamivir: one developed rash during treatment; no other adverse events were noticed. All children survived without sequelae. In conclusions, 2009 H1N1 influenza virus infection in children is associated with a wide spectrum of clinical manifestations. Neurological disorders are not exceptional complications. Oseltamivir therapy seems safe also in infants.
PMID: 20652313 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20652313