tetano
Editor, Senior Moderator
Vaccine. 2014 Jun 12. pii: S0264-410X(14)00368-5. doi: 10.1016/j.vaccine.2014.03.024. [Epub ahead of print]
Clinical evaluation of a novel microneedle device for intradermal delivery of an influenza vaccine: Are all delivery methods the same?
Levin Y1, Kochba E2, Kenney R3.
Author information
Abstract
The skin provides the largest immune barrier to infection and is a readily accessible site for vaccination, although intradermal (ID) injection can be challenging. The MicronJet? microneedle is a novel device that simply and consistently injects antigens very close to the skin's dendritic cells. A dose-sparing ID injection study was conducted in 280 healthy adult volunteers using trivalent virosomal adjuvanted influenza vaccine. ID injection of 3μg using the MicronJet? was well tolerated and showed a statistically higher geometric mean fold rise than the same dose ID using a conventional needle (Mantoux technique) for the H1N1 and B strains or a 15μg intramuscular (IM) injection for the H3N2 strain. Thus, the immune response appears to partially depend on the delivery device and route of injection. The MicronJet? may allow dose-sparing, yet give a superior response in influenza vaccination and warrants further clinical evaluation.
Copyright ? 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:
Dose-sparing; Immunogenicity; Influenza vaccination; Intradermal; Mantoux; Microneedle device
PMID:
24930715
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24930715
Clinical evaluation of a novel microneedle device for intradermal delivery of an influenza vaccine: Are all delivery methods the same?
Levin Y1, Kochba E2, Kenney R3.
Author information
Abstract
The skin provides the largest immune barrier to infection and is a readily accessible site for vaccination, although intradermal (ID) injection can be challenging. The MicronJet? microneedle is a novel device that simply and consistently injects antigens very close to the skin's dendritic cells. A dose-sparing ID injection study was conducted in 280 healthy adult volunteers using trivalent virosomal adjuvanted influenza vaccine. ID injection of 3μg using the MicronJet? was well tolerated and showed a statistically higher geometric mean fold rise than the same dose ID using a conventional needle (Mantoux technique) for the H1N1 and B strains or a 15μg intramuscular (IM) injection for the H3N2 strain. Thus, the immune response appears to partially depend on the delivery device and route of injection. The MicronJet? may allow dose-sparing, yet give a superior response in influenza vaccination and warrants further clinical evaluation.
Copyright ? 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:
Dose-sparing; Immunogenicity; Influenza vaccination; Intradermal; Mantoux; Microneedle device
PMID:
24930715
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24930715