tetano
Editor, Senior Moderator
J Infect Dis. 2018 May 28. doi: 10.1093/infdis/jiy317. [Epub ahead of print]
[h=1]Clinical Correlations of Transcriptional Profile in Patients Infected with Avian Influenza H7N9 Virus.[/h] Guan W[SUP]1[/SUP], Wu NC[SUP]2[/SUP], Lee HHY[SUP]3[/SUP], Li Y[SUP]1[/SUP], Jiang W[SUP]4[/SUP], Shen L[SUP]5[/SUP], Wu DC[SUP]6[/SUP], Chen R[SUP]1[/SUP], Zhong N[SUP]1[/SUP], Wilson IA[SUP]2,[/SUP][SUP]7[/SUP], Peiris M[SUP]1,[/SUP][SUP]3[/SUP], Yang Z[SUP]1[/SUP], Mok CKP[SUP]1,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis.
[h=4]Methods:[/h] We correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis.
[h=4]Results:[/h] We found that specific gene expression profiles in the blood were strongly correlated with the PaO2/FiO2 ratio and viral load in the lower respiratory tract (LRT). Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T cell functions and various metabolic processes were associated with the recovery phase of the illness. A transition from systemic innate to adaptive immunity was found.
[h=4]Conclusions:[/h] We developed a novel approach for transcriptomic analysis to identify key host responses that were strongly correlated with specific clinical and virologic parameters in patients with H7N9 infection.
PMID: 29846612 DOI: 10.1093/infdis/jiy317
[h=1]Clinical Correlations of Transcriptional Profile in Patients Infected with Avian Influenza H7N9 Virus.[/h] Guan W[SUP]1[/SUP], Wu NC[SUP]2[/SUP], Lee HHY[SUP]3[/SUP], Li Y[SUP]1[/SUP], Jiang W[SUP]4[/SUP], Shen L[SUP]5[/SUP], Wu DC[SUP]6[/SUP], Chen R[SUP]1[/SUP], Zhong N[SUP]1[/SUP], Wilson IA[SUP]2,[/SUP][SUP]7[/SUP], Peiris M[SUP]1,[/SUP][SUP]3[/SUP], Yang Z[SUP]1[/SUP], Mok CKP[SUP]1,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis.
[h=4]Methods:[/h] We correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis.
[h=4]Results:[/h] We found that specific gene expression profiles in the blood were strongly correlated with the PaO2/FiO2 ratio and viral load in the lower respiratory tract (LRT). Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T cell functions and various metabolic processes were associated with the recovery phase of the illness. A transition from systemic innate to adaptive immunity was found.
[h=4]Conclusions:[/h] We developed a novel approach for transcriptomic analysis to identify key host responses that were strongly correlated with specific clinical and virologic parameters in patients with H7N9 infection.
PMID: 29846612 DOI: 10.1093/infdis/jiy317