tetano
Editor, Senior Moderator
Yale J Biol Med. 2017 Jun 23;90(2):165-181. eCollection 2017 Jun.
[h=1]Clinical Characteristics of Influenza-Associated Pneumonia of Adults: Clinical Features and Factors Contributing to Severity and Mortality.[/h] Ishiguro T[SUP]1[/SUP], Kagiyama N[SUP]1[/SUP], Uozumi R[SUP]2[/SUP], Odashima K[SUP]1[/SUP], Takaku Y[SUP]1[/SUP], Kurashima K[SUP]1[/SUP], Morita S[SUP]2[/SUP], Takayanagi N[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Background: Pneumonia is a major complication of influenza that contributes to mortality. Clinical characteristics and factors of influenza virus contributing to the severity and mortality of pneumonia have not been fully elucidated. Objective: The objective was to clarify clinical characteristics and factors contributing to the severity and mortality of influenza-associated pneumonia (flu-p). Methods: We retrospectively analyzed patients with flu-p. Results: From December 1999 to March 2016, 210 patients with a median age of 69 (range, 17 to 92) years with flu-p based on positive rapid antigen tests, increased antibody titers of paired sera, or positive results of reverse transcription polymerase chain reaction were admitted to our institution. A multivariate analysis found that advanced age (≥ 65 years), pneumonia subtypes (unclassified), diabetes mellitus, and acute kidney injury complicated with flu-p were independent factors associated with disease severity, whereas pneumonia subtypes (mixed viral and bacterial pneumonia and unclassified), healthcare-associated pneumonia, acute kidney injury complicated with flu-p, and severity on admission (severe) were independent factors associated with non-survival. Conclusion: The clinical characteristics of flu-p are varied, and the contribution of several factors to the severity and mortality of flu-p suggest their importance in either preventing flu-p or managing flu-p after it develops.
[h=4]KEYWORDS:[/h] influenza associated pneumonia; outcome; prognosis; prognostic factor; severity
PMID: 28656006
[h=1]Clinical Characteristics of Influenza-Associated Pneumonia of Adults: Clinical Features and Factors Contributing to Severity and Mortality.[/h] Ishiguro T[SUP]1[/SUP], Kagiyama N[SUP]1[/SUP], Uozumi R[SUP]2[/SUP], Odashima K[SUP]1[/SUP], Takaku Y[SUP]1[/SUP], Kurashima K[SUP]1[/SUP], Morita S[SUP]2[/SUP], Takayanagi N[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Background: Pneumonia is a major complication of influenza that contributes to mortality. Clinical characteristics and factors of influenza virus contributing to the severity and mortality of pneumonia have not been fully elucidated. Objective: The objective was to clarify clinical characteristics and factors contributing to the severity and mortality of influenza-associated pneumonia (flu-p). Methods: We retrospectively analyzed patients with flu-p. Results: From December 1999 to March 2016, 210 patients with a median age of 69 (range, 17 to 92) years with flu-p based on positive rapid antigen tests, increased antibody titers of paired sera, or positive results of reverse transcription polymerase chain reaction were admitted to our institution. A multivariate analysis found that advanced age (≥ 65 years), pneumonia subtypes (unclassified), diabetes mellitus, and acute kidney injury complicated with flu-p were independent factors associated with disease severity, whereas pneumonia subtypes (mixed viral and bacterial pneumonia and unclassified), healthcare-associated pneumonia, acute kidney injury complicated with flu-p, and severity on admission (severe) were independent factors associated with non-survival. Conclusion: The clinical characteristics of flu-p are varied, and the contribution of several factors to the severity and mortality of flu-p suggest their importance in either preventing flu-p or managing flu-p after it develops.
[h=4]KEYWORDS:[/h] influenza associated pneumonia; outcome; prognosis; prognostic factor; severity
PMID: 28656006