tetano
Editor, Senior Moderator
PLoS One. 2015 Sep 1;10(9):e0136186. doi: 10.1371/journal.pone.0136186. eCollection 2015.
[h=1]Clinical Characteristics Are Similar across Type A and B Influenza Virus Infections.[/h] Mosnier A[SUP]1[/SUP], Caini S[SUP]1[/SUP], Daviaud I[SUP]1[/SUP], Nauleau E[SUP]1[/SUP], Bui TT[SUP]1[/SUP], Debost E[SUP]2[/SUP], Bedouret B[SUP]2[/SUP], Agius G[SUP]3[/SUP], van der Werf S[SUP]4[/SUP], Lina B[SUP]5[/SUP], Cohen JM[SUP]1[/SUP]; GROG network.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Studies that aimed at comparing the clinical presentation of influenza patients across virus types and subtypes/lineages found divergent results, but this was never investigated using data collected over several years in a countrywide, primary care practitioners-based influenza surveillance system.
[h=4]METHODS:[/h] The IBVD (Influenza B in Vircases Database) study collected information on signs and symptoms at disease onset from laboratory-confirmed influenza patients of any age who consulted a sentinel practitioner in France. We compared the clinical presentation of influenza patients across age groups (0-4, 5-14, 15-64 and 65+ years), virus types (A, B) and subtypes/lineages (A(H3N2), pandemic A(H1N1), B Victoria, B Yamagata).
[h=4]RESULTS:[/h] Overall, 14,423 influenza cases (23.9% of which were influenza B) were included between 2003-2004 and 2012-2013. Influenza A and B accounted for over 50% of total influenza cases during eight and two seasons, respectively. There were minor differences in the distribution of signs and symptoms across influenza virus types and subtypes/lineages. Compared to patients aged 0-4 years, those aged 5-14 years were more likely to have been infected with type B viruses (OR 2.15, 95% CI 1.87-2.47) while those aged 15-64 years were less likely (OR 0.83, 95% CI 0.73-0.96). Males and influenza patients diagnosed during the epidemic period were less likely to be infected with type B viruses.
[h=4]CONCLUSIONS:[/h] Despite differences in age distribution, the clinical illness produced by the different influenza virus types and subtypes is indistinguishable among patients that consult a general practitioner for acute respiratory infections.
PMID: 26325069 [PubMed - in process] Free full text
[h=1]Clinical Characteristics Are Similar across Type A and B Influenza Virus Infections.[/h] Mosnier A[SUP]1[/SUP], Caini S[SUP]1[/SUP], Daviaud I[SUP]1[/SUP], Nauleau E[SUP]1[/SUP], Bui TT[SUP]1[/SUP], Debost E[SUP]2[/SUP], Bedouret B[SUP]2[/SUP], Agius G[SUP]3[/SUP], van der Werf S[SUP]4[/SUP], Lina B[SUP]5[/SUP], Cohen JM[SUP]1[/SUP]; GROG network.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Studies that aimed at comparing the clinical presentation of influenza patients across virus types and subtypes/lineages found divergent results, but this was never investigated using data collected over several years in a countrywide, primary care practitioners-based influenza surveillance system.
[h=4]METHODS:[/h] The IBVD (Influenza B in Vircases Database) study collected information on signs and symptoms at disease onset from laboratory-confirmed influenza patients of any age who consulted a sentinel practitioner in France. We compared the clinical presentation of influenza patients across age groups (0-4, 5-14, 15-64 and 65+ years), virus types (A, B) and subtypes/lineages (A(H3N2), pandemic A(H1N1), B Victoria, B Yamagata).
[h=4]RESULTS:[/h] Overall, 14,423 influenza cases (23.9% of which were influenza B) were included between 2003-2004 and 2012-2013. Influenza A and B accounted for over 50% of total influenza cases during eight and two seasons, respectively. There were minor differences in the distribution of signs and symptoms across influenza virus types and subtypes/lineages. Compared to patients aged 0-4 years, those aged 5-14 years were more likely to have been infected with type B viruses (OR 2.15, 95% CI 1.87-2.47) while those aged 15-64 years were less likely (OR 0.83, 95% CI 0.73-0.96). Males and influenza patients diagnosed during the epidemic period were less likely to be infected with type B viruses.
[h=4]CONCLUSIONS:[/h] Despite differences in age distribution, the clinical illness produced by the different influenza virus types and subtypes is indistinguishable among patients that consult a general practitioner for acute respiratory infections.
PMID: 26325069 [PubMed - in process] Free full text