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doi:10.1016/j.jinf.2011.11.022 | How to Cite or Link Using DOI
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Clinical characteristics and outcomes of diabetes sufferers hospitalized from 2009 pandemic influenza a h1n1 infections
Marta Cortes Garcia1, Maria Jose Sierra Moros1, Corresponding Author Contact Information, E-mail The Corresponding Author, Patricia Santa-Olalla Peralta1, Valentin Hernandez-Barrera2, Rodrigo Jimenez-Garcia2, Isabel Pachon1
1 Coordinating Centre for Health Alerts and Emergencies (CCAES), Ministry of Health and Social Policy Paseo del Prado 18-20, 28071 Madrid. Spain
2 Health Science Faculty. URJC. Av Atenas sn. 28922 Alcorcon. Madrid. Spain
Received 13 April 2010; revised 5 October 2011; Accepted 19 November 2011. Available online 25 November 2011.
Abstract
Objectives
To describe demographic and clinical data and outcomes of severe cases of 2009 pandemic influenza A H1N1 (pH1N1) infections for persons with diabetes.
Methods
We selected all person with diabetes (N=252) among severe laboratory confirmed cases reported to the Spanish Surveillance System for detection of pH1N1 from June through December, 2009. One patient without diabetes matched by age and sex was selected. Collected variables included demographic characteristics, underlying medical conditions, outcome, clinical course and treatment.
Results
Among those suffering diabetes only 15.9% did not report any other underlying condition. 38% of diabetic patients and 27.4% of non diabetic patients were admitted to ICU (p=0.008). Thirty subjects suffering diabetes and fifteen without the disease died (11.9% vs. 6%[p=0.019]). Multivariable analysis showed that the independent risk factors for ICU admission or death were suffering cardiovascular disease (OR=2.28), morbid obesity (OR=2.08) and antiviral treatment started after 48 hours of onset of symptoms (OR=1.89). Suffering diabetes was not independent risk factors for ICU admission or death after adjusting for covariates.
Conclusions
The worse outcome among diabetes sufferers could be a consequence of the higher prevalence of comorbid underlying medical conditions but not diabetes itself. Further prospective studies are needed to verify these results.
http://www.sciencedirect.com/science/article/pii/S016344531100572X
Permissions & Reprints
Clinical characteristics and outcomes of diabetes sufferers hospitalized from 2009 pandemic influenza a h1n1 infections
Marta Cortes Garcia1, Maria Jose Sierra Moros1, Corresponding Author Contact Information, E-mail The Corresponding Author, Patricia Santa-Olalla Peralta1, Valentin Hernandez-Barrera2, Rodrigo Jimenez-Garcia2, Isabel Pachon1
1 Coordinating Centre for Health Alerts and Emergencies (CCAES), Ministry of Health and Social Policy Paseo del Prado 18-20, 28071 Madrid. Spain
2 Health Science Faculty. URJC. Av Atenas sn. 28922 Alcorcon. Madrid. Spain
Received 13 April 2010; revised 5 October 2011; Accepted 19 November 2011. Available online 25 November 2011.
Abstract
Objectives
To describe demographic and clinical data and outcomes of severe cases of 2009 pandemic influenza A H1N1 (pH1N1) infections for persons with diabetes.
Methods
We selected all person with diabetes (N=252) among severe laboratory confirmed cases reported to the Spanish Surveillance System for detection of pH1N1 from June through December, 2009. One patient without diabetes matched by age and sex was selected. Collected variables included demographic characteristics, underlying medical conditions, outcome, clinical course and treatment.
Results
Among those suffering diabetes only 15.9% did not report any other underlying condition. 38% of diabetic patients and 27.4% of non diabetic patients were admitted to ICU (p=0.008). Thirty subjects suffering diabetes and fifteen without the disease died (11.9% vs. 6%[p=0.019]). Multivariable analysis showed that the independent risk factors for ICU admission or death were suffering cardiovascular disease (OR=2.28), morbid obesity (OR=2.08) and antiviral treatment started after 48 hours of onset of symptoms (OR=1.89). Suffering diabetes was not independent risk factors for ICU admission or death after adjusting for covariates.
Conclusions
The worse outcome among diabetes sufferers could be a consequence of the higher prevalence of comorbid underlying medical conditions but not diabetes itself. Further prospective studies are needed to verify these results.
http://www.sciencedirect.com/science/article/pii/S016344531100572X