tetano
Editor, Senior Moderator
Clin Transplant
. 2021 Jan 6;e14216.
doi: 10.1111/ctr.14216. Online ahead of print.
Outcomes of COVID-19 in hospitalized solid organ transplant recipients compared to a matched cohort of non-transplant patients at a national healthcare system in the United states
Arielle M Fisher[SUP] 1 2 [/SUP], Daniel Schlauch[SUP] 1 2 [/SUP], Matthew Mulloy[SUP] 3 [/SUP], Ann Dao[SUP] 4 [/SUP], Ashraf I Reyad[SUP] 4 [/SUP], Mick Correll[SUP] 1 2 [/SUP], Gregg J Fromell[SUP] 2 5 [/SUP], James Pittman[SUP] 5 [/SUP], Adam W Bingaman[SUP] 6 [/SUP], Balamurugan Sankarapandian[SUP] 4 7 [/SUP], Sridhar R Allam[SUP] 4 7 [/SUP]
Affiliations
Abstract
Data describing outcomes of solid organ transplant (SOT) recipients with coronavirus disease 2019 (COVID-19) are variable, and the association between SOT status and mortality remains unclear. In this study, we compare clinical outcomes of SOT recipients hospitalized with COVID-19 between March 10 and September 1, 2020 to a matched cohort of non-SOT recipients at a national healthcare system in the United States (US). From a population of 43,461 hospitalized COVID-19 positive patients, we created a coarsened exact matched cohort of 4,035 patients including 128 SOT recipients and 3,907 weighted matched non-SOT controls. Multiple logistic regression was used to evaluate association between SOT status and clinical outcomes. Among the 4,035 patients, median age was 60 years, 61.7% were male, 21.9% were Black/African American, and 50.8% identified as Hispanic/Latino ethnicity. Patients with a history of SOT were more likely to die within the study period when compared to matched non-SOT recipients (21.9% and 14.9%, respectively; odds ratio [OR] 1.93; 95% confidence interval [CI]: 1.18-3.15). Moreover, SOT status was associated with increased odds of receiving invasive mechanical ventilation (OR [95% CI]: 2.34 [1.51-3.65]), developing acute kidney injury (OR [95% CI]: 2.41 [1.59-3.65]), and receiving vasopressor support during hospitalization (OR [95% CI]: 2.14 [1.31-3.48]).
Keywords: COVID-19; Outcomes; Solid organ transplant.
. 2021 Jan 6;e14216.
doi: 10.1111/ctr.14216. Online ahead of print.
Outcomes of COVID-19 in hospitalized solid organ transplant recipients compared to a matched cohort of non-transplant patients at a national healthcare system in the United states
Arielle M Fisher[SUP] 1 2 [/SUP], Daniel Schlauch[SUP] 1 2 [/SUP], Matthew Mulloy[SUP] 3 [/SUP], Ann Dao[SUP] 4 [/SUP], Ashraf I Reyad[SUP] 4 [/SUP], Mick Correll[SUP] 1 2 [/SUP], Gregg J Fromell[SUP] 2 5 [/SUP], James Pittman[SUP] 5 [/SUP], Adam W Bingaman[SUP] 6 [/SUP], Balamurugan Sankarapandian[SUP] 4 7 [/SUP], Sridhar R Allam[SUP] 4 7 [/SUP]
Affiliations
- PMID: 33406279
- DOI: 10.1111/ctr.14216
Abstract
Data describing outcomes of solid organ transplant (SOT) recipients with coronavirus disease 2019 (COVID-19) are variable, and the association between SOT status and mortality remains unclear. In this study, we compare clinical outcomes of SOT recipients hospitalized with COVID-19 between March 10 and September 1, 2020 to a matched cohort of non-SOT recipients at a national healthcare system in the United States (US). From a population of 43,461 hospitalized COVID-19 positive patients, we created a coarsened exact matched cohort of 4,035 patients including 128 SOT recipients and 3,907 weighted matched non-SOT controls. Multiple logistic regression was used to evaluate association between SOT status and clinical outcomes. Among the 4,035 patients, median age was 60 years, 61.7% were male, 21.9% were Black/African American, and 50.8% identified as Hispanic/Latino ethnicity. Patients with a history of SOT were more likely to die within the study period when compared to matched non-SOT recipients (21.9% and 14.9%, respectively; odds ratio [OR] 1.93; 95% confidence interval [CI]: 1.18-3.15). Moreover, SOT status was associated with increased odds of receiving invasive mechanical ventilation (OR [95% CI]: 2.34 [1.51-3.65]), developing acute kidney injury (OR [95% CI]: 2.41 [1.59-3.65]), and receiving vasopressor support during hospitalization (OR [95% CI]: 2.14 [1.31-3.48]).
Keywords: COVID-19; Outcomes; Solid organ transplant.