tetano
Editor, Senior Moderator
Clin Transl Med
. 2022 Apr;12(4):e802.
doi: 10.1002/ctm2.802.
Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response
Alberto Pérez-Gómez[SUP] 1 [/SUP], Carmen Gasca-Capote[SUP] 1 [/SUP], Joana Vitallé[SUP] 1 [/SUP], Francisco J Ostos[SUP] 1 2 [/SUP], Ana Serna-Gallego[SUP] 1 [/SUP], María Trujillo-Rodríguez[SUP] 1 [/SUP], Esperanza Muñoz-Muela[SUP] 1 [/SUP], Teresa Giráldez-Pérez[SUP] 1 [/SUP], Julia Praena-Segovia[SUP] 1 [/SUP], María D Navarro-Amuedo[SUP] 1 [/SUP], María Paniagua-García[SUP] 1 [/SUP], Manuel García-Gutiérrez[SUP] 1 [/SUP], Manuela Aguilar-Guisado[SUP] 1 [/SUP], Inmaculada Rivas-Jeremías[SUP] 1 [/SUP], María Reyes Jiménez-León[SUP] 1 [/SUP], Sara Bachiller[SUP] 1 [/SUP], Alberto Fernández-Villar[SUP] 3 [/SUP], Alexandre Pérez-González[SUP] 4 5 [/SUP], Alicia Gutiérrez-Valencia[SUP] 1 [/SUP], Mohammed Rafii-El-Idrissi Benhnia[SUP] 1 2 [/SUP], Daniela Weiskopf[SUP] 6 [/SUP], Alessandro Sette[SUP] 6 7 [/SUP], Luis F López-Cortés[SUP] 1 [/SUP], Eva Poveda[SUP] 4 [/SUP], Ezequiel Ruiz-Mateos[SUP] 1 [/SUP], Virgen del Rocío Hospital COVID-19 and COHVID-GS Working Teams[SUP] 1 [/SUP]
Affiliations
Abstract
SARS-CoV-2 specific T-cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality of SARS-CoV-2 specific T-cell response with antibody levels in these three scenarios is needed. In the present study, we found that, in acute infection, while mild disease was associated with high T-cell polyfunctionality biased to IL-2 production and inversely correlated with anti-S IgG levels, combinations only including IFN-γ with the absence of perforin production predominated in severe disease. Seven months after infection, both non-hospitalised and previously hospitalised patients presented robust anti-S IgG levels and SARS-CoV-2 specific T-cell response. In addition, only previously hospitalised patients showed a T-cell exhaustion profile. Finally, combinations including IL-2 in response to S protein of endemic coronaviruses were the ones associated with SARS-CoV-2 S-specific T-cell response in pre-COVID-19 healthy donors' samples. These results could have implications for protective immunity against SARS-CoV-2 and recurrent COVID-19 and may help for the design of new prototypes and boosting vaccine strategies.
Keywords: COVID-19; IL-2; SARS-CoV-2; Spike; T-cell response; endemic coronaviruses; nucleocapsid; polyfunctionality.
. 2022 Apr;12(4):e802.
doi: 10.1002/ctm2.802.
Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response
Alberto Pérez-Gómez[SUP] 1 [/SUP], Carmen Gasca-Capote[SUP] 1 [/SUP], Joana Vitallé[SUP] 1 [/SUP], Francisco J Ostos[SUP] 1 2 [/SUP], Ana Serna-Gallego[SUP] 1 [/SUP], María Trujillo-Rodríguez[SUP] 1 [/SUP], Esperanza Muñoz-Muela[SUP] 1 [/SUP], Teresa Giráldez-Pérez[SUP] 1 [/SUP], Julia Praena-Segovia[SUP] 1 [/SUP], María D Navarro-Amuedo[SUP] 1 [/SUP], María Paniagua-García[SUP] 1 [/SUP], Manuel García-Gutiérrez[SUP] 1 [/SUP], Manuela Aguilar-Guisado[SUP] 1 [/SUP], Inmaculada Rivas-Jeremías[SUP] 1 [/SUP], María Reyes Jiménez-León[SUP] 1 [/SUP], Sara Bachiller[SUP] 1 [/SUP], Alberto Fernández-Villar[SUP] 3 [/SUP], Alexandre Pérez-González[SUP] 4 5 [/SUP], Alicia Gutiérrez-Valencia[SUP] 1 [/SUP], Mohammed Rafii-El-Idrissi Benhnia[SUP] 1 2 [/SUP], Daniela Weiskopf[SUP] 6 [/SUP], Alessandro Sette[SUP] 6 7 [/SUP], Luis F López-Cortés[SUP] 1 [/SUP], Eva Poveda[SUP] 4 [/SUP], Ezequiel Ruiz-Mateos[SUP] 1 [/SUP], Virgen del Rocío Hospital COVID-19 and COHVID-GS Working Teams[SUP] 1 [/SUP]
Affiliations
- PMID: 35415890
- DOI: 10.1002/ctm2.802
Abstract
SARS-CoV-2 specific T-cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality of SARS-CoV-2 specific T-cell response with antibody levels in these three scenarios is needed. In the present study, we found that, in acute infection, while mild disease was associated with high T-cell polyfunctionality biased to IL-2 production and inversely correlated with anti-S IgG levels, combinations only including IFN-γ with the absence of perforin production predominated in severe disease. Seven months after infection, both non-hospitalised and previously hospitalised patients presented robust anti-S IgG levels and SARS-CoV-2 specific T-cell response. In addition, only previously hospitalised patients showed a T-cell exhaustion profile. Finally, combinations including IL-2 in response to S protein of endemic coronaviruses were the ones associated with SARS-CoV-2 S-specific T-cell response in pre-COVID-19 healthy donors' samples. These results could have implications for protective immunity against SARS-CoV-2 and recurrent COVID-19 and may help for the design of new prototypes and boosting vaccine strategies.
Keywords: COVID-19; IL-2; SARS-CoV-2; Spike; T-cell response; endemic coronaviruses; nucleocapsid; polyfunctionality.