tetano
Editor, Senior Moderator
Clin Respir J
. 2021 Apr 25.
doi: 10.1111/crj.13381. Online ahead of print.
Laboratory predictors of severe Coronavirus Disease 2019 and lung function in followed-up
Min Pan[SUP] 1 2 3 [/SUP], Rui-Rui Wang[SUP] 1 4 5 [/SUP], Xu Chen[SUP] 1 2 3 [/SUP], Jun Han[SUP] 6 [/SUP], Qiang Li[SUP] 4 5 [/SUP], Manli Miao[SUP] 1 2 3 [/SUP], Jianguo Rao[SUP] 7 [/SUP], Jizheng Huang[SUP] 4 5 [/SUP], Long Yu[SUP] 7 [/SUP], Yufei Xu[SUP] 1 2 3 8 [/SUP], Lingli Li[SUP] 4 5 [/SUP], Qiang Shao[SUP] 6 [/SUP], Hengli Ma[SUP] 1 2 3 8 [/SUP], Mingfeng Han[SUP] 4 5 [/SUP], Xiaoyun Fan[SUP] 1 2 3 8 [/SUP]
Affiliations
Abstract
Background: A pandemic caused by SARS-CoV-2 has infected more than 79 million people and killed exceeding 1.7 million people around the world by the end of 2020.
Method: We obtained the clinical data of all diagnosed patients and lung function test of followed-up patients in Fuyang, Anhui province to investigate laboratory predictors of severe COVID-19 and the impairment of lung function.
Results: Of the 155 patients, 87(56.13%) were males. The mean age was 41.95 (SD 15.34) years. Only 30(19.35%) patients had critical condition. Fever (84.52%) were the most common symptoms, and short of breath was more common in severe patients (P<0.01). Lymphopenia was observed in most patients (74, 47.7%). It showed the elevation of CRP in 100 (64.5%) patients, the elevation of SAA or IL-6 in 104 (67.1%) patients. The calculated cut-off value of CRP was 19.35 mg/mL, the AUC was 0.777, sensitivity was 73.3%, specificity was 69.6%; SAA was 73.55 mg/L, 0.679, 83.3%, 56.8% respectively; IL-6 was 18.85 pg/mL, 0.797, 83.3%, 64.8%; D-Dimer was 0.325 mg/L, 0.673, 66.7% and 68.8%. The combination of CRP, SAA, IL-6 and D-Dimer was 0.823 in AUC, 73.3% in sensitivity and 78.4% in specificity. 12(42.86%) followed-up patients had completely normal lung function indicators.
Conclusion: Elevated CRP, SAA, IL-6 and D-Dimer can be predictors to severe COVID-19. The combination of these four indicators can improve the effectivity and specificity of assessing severe COVID-19. Most of the followed-up patients showed no abnormalities in lung function test. Abnormal lung function is mainly reflected in the diffusion function.
Keywords: COVID-19; Followed-up; Lung function; ROC curve; SARS-CoV-2; predictors.
. 2021 Apr 25.
doi: 10.1111/crj.13381. Online ahead of print.
Laboratory predictors of severe Coronavirus Disease 2019 and lung function in followed-up
Min Pan[SUP] 1 2 3 [/SUP], Rui-Rui Wang[SUP] 1 4 5 [/SUP], Xu Chen[SUP] 1 2 3 [/SUP], Jun Han[SUP] 6 [/SUP], Qiang Li[SUP] 4 5 [/SUP], Manli Miao[SUP] 1 2 3 [/SUP], Jianguo Rao[SUP] 7 [/SUP], Jizheng Huang[SUP] 4 5 [/SUP], Long Yu[SUP] 7 [/SUP], Yufei Xu[SUP] 1 2 3 8 [/SUP], Lingli Li[SUP] 4 5 [/SUP], Qiang Shao[SUP] 6 [/SUP], Hengli Ma[SUP] 1 2 3 8 [/SUP], Mingfeng Han[SUP] 4 5 [/SUP], Xiaoyun Fan[SUP] 1 2 3 8 [/SUP]
Affiliations
- PMID: 33896114
- DOI: 10.1111/crj.13381
Abstract
Background: A pandemic caused by SARS-CoV-2 has infected more than 79 million people and killed exceeding 1.7 million people around the world by the end of 2020.
Method: We obtained the clinical data of all diagnosed patients and lung function test of followed-up patients in Fuyang, Anhui province to investigate laboratory predictors of severe COVID-19 and the impairment of lung function.
Results: Of the 155 patients, 87(56.13%) were males. The mean age was 41.95 (SD 15.34) years. Only 30(19.35%) patients had critical condition. Fever (84.52%) were the most common symptoms, and short of breath was more common in severe patients (P<0.01). Lymphopenia was observed in most patients (74, 47.7%). It showed the elevation of CRP in 100 (64.5%) patients, the elevation of SAA or IL-6 in 104 (67.1%) patients. The calculated cut-off value of CRP was 19.35 mg/mL, the AUC was 0.777, sensitivity was 73.3%, specificity was 69.6%; SAA was 73.55 mg/L, 0.679, 83.3%, 56.8% respectively; IL-6 was 18.85 pg/mL, 0.797, 83.3%, 64.8%; D-Dimer was 0.325 mg/L, 0.673, 66.7% and 68.8%. The combination of CRP, SAA, IL-6 and D-Dimer was 0.823 in AUC, 73.3% in sensitivity and 78.4% in specificity. 12(42.86%) followed-up patients had completely normal lung function indicators.
Conclusion: Elevated CRP, SAA, IL-6 and D-Dimer can be predictors to severe COVID-19. The combination of these four indicators can improve the effectivity and specificity of assessing severe COVID-19. Most of the followed-up patients showed no abnormalities in lung function test. Abnormal lung function is mainly reflected in the diffusion function.
Keywords: COVID-19; Followed-up; Lung function; ROC curve; SARS-CoV-2; predictors.