tetano
Editor, Senior Moderator
Clin Respir J
. 2025 Apr;19(4):e70070.
doi: 10.1111/crj.70070. Implication of Admission Eosinophil Count and Prognosis of Coronavirus Disease 2019 (COVID-19) in Elderly Patients With COPD: A Territory-Wide Cohort Study
Wang Chun Kwok[SUP] 1 [/SUP], Yat Fung Shea[SUP] 1 [/SUP], James Chung Man Ho[SUP] 1 [/SUP], David Chi Leung Lam[SUP] 1 [/SUP], Terence Chi Chun Tam[SUP] 1 [/SUP], Anthony Raymond Tam[SUP] 1 [/SUP], Mary Sau Man Ip[SUP] 1 [/SUP], Ivan Fan Ngai Hung[SUP] 1 [/SUP]
Affiliations
Objectives: This study aims to investigate the association between elderly patients with COPD with different blood eosinophil on admission and those without COPD and the prognosis of COVID-19.
Method: A territory-wide retrospective study was conducted to investigate the association between elderly COPD patients with different blood eosinophil on admission and the prognosis of COVID-19. Elderly patients admitted to public hospitals and community treatment facility in Hong Kong for COVID-19 from January 23, 2020, to September 31, 2021, were included in the study. Severe diseases were defined as those who develop respiratory complications, systemic complications and death.
Results: Among the 1925 patients included, 133 had COPD. Forty had admission blood eosinophil count ≥ 150 cells/μL, and 93 had blood eosinophil count < 150 cells/μL. Patients with COPD and admission blood eosinophil count ≥ 150 cells/μL, but not those with admission blood eosinophil count < 150 cells/μL, had severe COVID-19 with the development of respiratory and systemic complications. They were more likely to develop respiratory failure (OR = 5.235, 95% CI = 2.088-13.122, p < 0.001) and require invasive mechanical ventilation (OR = 2.433, 95% CI = 1.022-5.791, p = 0.045) and intensive care unit admission (OR = 2.214, 95% CI = 1.004-4.881, p = 0.049).
Discussion: Our study suggested that the blood eosinophil count on admission could have significant prognostic implications among elderly patients with COPD. Patients with COPD and admission blood eosinophil count ≥ 150 cells/μL, but not those with admission blood eosinophil count < 150 cells/μL, have significantly increased risks of developing respiratory and systemic complications from COVID-19, when compared with non-COPD patients.
Keywords: COVID‐19; SARS‐CoV‐2; chronic obstructive pulmonary disease; eosinophilic phenotype.
. 2025 Apr;19(4):e70070.
doi: 10.1111/crj.70070. Implication of Admission Eosinophil Count and Prognosis of Coronavirus Disease 2019 (COVID-19) in Elderly Patients With COPD: A Territory-Wide Cohort Study
Wang Chun Kwok[SUP] 1 [/SUP], Yat Fung Shea[SUP] 1 [/SUP], James Chung Man Ho[SUP] 1 [/SUP], David Chi Leung Lam[SUP] 1 [/SUP], Terence Chi Chun Tam[SUP] 1 [/SUP], Anthony Raymond Tam[SUP] 1 [/SUP], Mary Sau Man Ip[SUP] 1 [/SUP], Ivan Fan Ngai Hung[SUP] 1 [/SUP]
Affiliations
- PMID: 40143637
- DOI: 10.1111/crj.70070
Objectives: This study aims to investigate the association between elderly patients with COPD with different blood eosinophil on admission and those without COPD and the prognosis of COVID-19.
Method: A territory-wide retrospective study was conducted to investigate the association between elderly COPD patients with different blood eosinophil on admission and the prognosis of COVID-19. Elderly patients admitted to public hospitals and community treatment facility in Hong Kong for COVID-19 from January 23, 2020, to September 31, 2021, were included in the study. Severe diseases were defined as those who develop respiratory complications, systemic complications and death.
Results: Among the 1925 patients included, 133 had COPD. Forty had admission blood eosinophil count ≥ 150 cells/μL, and 93 had blood eosinophil count < 150 cells/μL. Patients with COPD and admission blood eosinophil count ≥ 150 cells/μL, but not those with admission blood eosinophil count < 150 cells/μL, had severe COVID-19 with the development of respiratory and systemic complications. They were more likely to develop respiratory failure (OR = 5.235, 95% CI = 2.088-13.122, p < 0.001) and require invasive mechanical ventilation (OR = 2.433, 95% CI = 1.022-5.791, p = 0.045) and intensive care unit admission (OR = 2.214, 95% CI = 1.004-4.881, p = 0.049).
Discussion: Our study suggested that the blood eosinophil count on admission could have significant prognostic implications among elderly patients with COPD. Patients with COPD and admission blood eosinophil count ≥ 150 cells/μL, but not those with admission blood eosinophil count < 150 cells/μL, have significantly increased risks of developing respiratory and systemic complications from COVID-19, when compared with non-COPD patients.
Keywords: COVID‐19; SARS‐CoV‐2; chronic obstructive pulmonary disease; eosinophilic phenotype.