tetano
Editor, Senior Moderator
Clin Res Cardiol
. 2022 Dec 24.
doi: 10.1007/s00392-022-02141-9. Online ahead of print.
Myocarditis mortality with and without COVID-19: insights from a national registry
Xavier Bemtgen[SUP] 1 [/SUP], Klaus Kaier[SUP] 2 [/SUP], Jonathan Rilinger[SUP] 3 [/SUP], Felix Rottmann[SUP] 4 [/SUP], Alexander Supady[SUP] 5 6 [/SUP], Constantin von Zur Mühlen[SUP] 3 [/SUP], Dirk Westermann[SUP] 3 [/SUP], Tobias Wengenmayer[SUP] 5 [/SUP], Dawid L Staudacher[SUP] 5 [/SUP]
Affiliations
Abstract
Background: Myocarditis in context of a SARS-CoV-2 infection is vividly discussed in the literature. Real-world data however are sparse, and relevance of the myocarditis diagnosis to outcome in coronavirus disease (COVID-19) is unclear.
Patients and methods: Retrospective analysis of 75,304 patients hospitalized in Germany with myocarditis between 2007 and 2020 is reported by DESTATIS. Patients hospitalized between 01/2016 and 12/2019 served as reference cohort for the COVID-19 patients hospitalized in 2020.
Results: A total of 75,304 patients were hospitalized between 2007 and 2020 (age 42.5 years, 30.1% female, hospital mortality 2.4%). In the reference cohort, 24,474 patients (age 42.8 years, 29.5% female, hospital mortality 2.2%) were registered. In 2020, annual myocarditis hospitalizations dropped by 19.6% compared to reference (4921 vs. 6119 annual hospitalization), of which 443/4921 (9.0%) were connected to COVID-19. In 2020, hospital mortality of myocarditis in non-COVID-19 patients increased significantly compared to reference (2.9% vs. 2.2%, p = 0.008, OR 1.31, 95% CI 1.08-1.60). In COVID-19 myocarditis, hospital mortality was even higher compared to reference (13.5% vs. 2.2%, p < 0.001, OR 6.93, 95% CI 5.18-9.18).
Conclusion: The burden of patients with myocarditis and COVID-19 in 2020 was low. Hospital mortality was more than sixfold higher in patients with myocarditis and COVID-19 compared to those with myocarditis but without COVID-19.
Keywords: COVID-19; Hospitalization; Myocarditis; National registry; SARS-CoV-2; Survival.
. 2022 Dec 24.
doi: 10.1007/s00392-022-02141-9. Online ahead of print.
Myocarditis mortality with and without COVID-19: insights from a national registry
Xavier Bemtgen[SUP] 1 [/SUP], Klaus Kaier[SUP] 2 [/SUP], Jonathan Rilinger[SUP] 3 [/SUP], Felix Rottmann[SUP] 4 [/SUP], Alexander Supady[SUP] 5 6 [/SUP], Constantin von Zur Mühlen[SUP] 3 [/SUP], Dirk Westermann[SUP] 3 [/SUP], Tobias Wengenmayer[SUP] 5 [/SUP], Dawid L Staudacher[SUP] 5 [/SUP]
Affiliations
- PMID: 36565377
- DOI: 10.1007/s00392-022-02141-9
Abstract
Background: Myocarditis in context of a SARS-CoV-2 infection is vividly discussed in the literature. Real-world data however are sparse, and relevance of the myocarditis diagnosis to outcome in coronavirus disease (COVID-19) is unclear.
Patients and methods: Retrospective analysis of 75,304 patients hospitalized in Germany with myocarditis between 2007 and 2020 is reported by DESTATIS. Patients hospitalized between 01/2016 and 12/2019 served as reference cohort for the COVID-19 patients hospitalized in 2020.
Results: A total of 75,304 patients were hospitalized between 2007 and 2020 (age 42.5 years, 30.1% female, hospital mortality 2.4%). In the reference cohort, 24,474 patients (age 42.8 years, 29.5% female, hospital mortality 2.2%) were registered. In 2020, annual myocarditis hospitalizations dropped by 19.6% compared to reference (4921 vs. 6119 annual hospitalization), of which 443/4921 (9.0%) were connected to COVID-19. In 2020, hospital mortality of myocarditis in non-COVID-19 patients increased significantly compared to reference (2.9% vs. 2.2%, p = 0.008, OR 1.31, 95% CI 1.08-1.60). In COVID-19 myocarditis, hospital mortality was even higher compared to reference (13.5% vs. 2.2%, p < 0.001, OR 6.93, 95% CI 5.18-9.18).
Conclusion: The burden of patients with myocarditis and COVID-19 in 2020 was low. Hospital mortality was more than sixfold higher in patients with myocarditis and COVID-19 compared to those with myocarditis but without COVID-19.
Keywords: COVID-19; Hospitalization; Myocarditis; National registry; SARS-CoV-2; Survival.