tetano
Editor, Senior Moderator
Clin Pediatr Endocrinol
. 2022;31(3):163-167.
doi: 10.1297/cpe.2022-0011. Epub 2022 Mar 30.
A case of adrenal insufficiency during multisystem inflammatory syndrome in children
Fatih Kilci[SUP] 1 [/SUP], Ayşe Filiz Yetimakman[SUP] 2 [/SUP], Jeremy Huw Jones[SUP] 3 [/SUP], Filiz Mine Çizmecioğlu[SUP] 1 [/SUP]
Affiliations
Abstract
Multisystem inflammatory syndrome in children (MIS-C) is a disease related to coronavirus disease 2019 (COVID-19). Although the effects of COVID-19 on many systems are known, there is limited data regarding its effects on the endocrine system. This study aimed to discuss the effect of COVID-19 on cortisol dynamics in a patient who developed adrenal insufficiency after COVID-19 infection. An 11-yr-old boy with polymerase chain reaction-proven COVID-19 one month previously was referred with a five-day history of fever, vomiting, and rash. On admission, he had hypotension, tachycardia, and severe hyponatremia. After the evaluation, he was diagnosed with MIS-C and glucocorticoid therapy was initiated. During follow-up, the patient experienced adrenal insufficiency, and hydrocortisone treatment was initiated at a crisis dose. Four months later, the adrenal axis function had not recovered. The adrenocortical response in COVID-19 patients may be significantly impaired, resulting in increased mortality or morbidity.
Keywords: adrenal insufficiency; coronavirus disease 2019 (COVID-19); cortisol.
. 2022;31(3):163-167.
doi: 10.1297/cpe.2022-0011. Epub 2022 Mar 30.
A case of adrenal insufficiency during multisystem inflammatory syndrome in children
Fatih Kilci[SUP] 1 [/SUP], Ayşe Filiz Yetimakman[SUP] 2 [/SUP], Jeremy Huw Jones[SUP] 3 [/SUP], Filiz Mine Çizmecioğlu[SUP] 1 [/SUP]
Affiliations
- PMID: 35928381
- PMCID: PMC9297178
- DOI: 10.1297/cpe.2022-0011
Abstract
Multisystem inflammatory syndrome in children (MIS-C) is a disease related to coronavirus disease 2019 (COVID-19). Although the effects of COVID-19 on many systems are known, there is limited data regarding its effects on the endocrine system. This study aimed to discuss the effect of COVID-19 on cortisol dynamics in a patient who developed adrenal insufficiency after COVID-19 infection. An 11-yr-old boy with polymerase chain reaction-proven COVID-19 one month previously was referred with a five-day history of fever, vomiting, and rash. On admission, he had hypotension, tachycardia, and severe hyponatremia. After the evaluation, he was diagnosed with MIS-C and glucocorticoid therapy was initiated. During follow-up, the patient experienced adrenal insufficiency, and hydrocortisone treatment was initiated at a crisis dose. Four months later, the adrenal axis function had not recovered. The adrenocortical response in COVID-19 patients may be significantly impaired, resulting in increased mortality or morbidity.
Keywords: adrenal insufficiency; coronavirus disease 2019 (COVID-19); cortisol.