tetano
Editor, Senior Moderator
Clin Neurophysiol
. 2022 Jun 15;140:126-135.
doi: 10.1016/j.clinph.2022.05.017. Online ahead of print.
High-density EEG sleep correlates of cognitive and affective impairment at 12-month follow-up after COVID-19
Maria Rubega[SUP] 1 [/SUP], Luciana Ciringione[SUP] 2 [/SUP], Margherita Bertuccelli[SUP] 3 [/SUP], Matilde Paramento[SUP] 4 [/SUP], Giovanni Sparacino[SUP] 5 [/SUP], Andrea Vianello[SUP] 6 [/SUP], Stefano Masiero[SUP] 7 [/SUP], Antonino Vallesi[SUP] 8 [/SUP], Emanuela Formaggio[SUP] 9 [/SUP], Alessandra Del Felice[SUP] 10 [/SUP]
Affiliations
Abstract
Objective: To disentangle the pathophysiology of cognitive/affective impairment in Coronavirus Disease-2019 (COVID-19), we studied long-term cognitive and affective sequelae and sleep high-density electroencephalography (EEG) at 12-month follow-up in people with a previous hospital admission for acute COVID-19.
Methods: People discharged from an intensive care unit (ICU) and a sub-intensive ward (nonICU) between March and May 2020 were contacted between March and June 2021. Participants underwent cognitive, psychological, and sleep assessment. High-density EEG recording was acquired during a nap. Slow and fast spindles density/amplitude/frequency and source reconstruction in brain gray matter were extracted. The relationship between psychological and cognitive findings was explored with Pearson correlation.
Results: We enrolled 33 participants ( 17 nonICU) and 12 controls. We observed a lower Physical Quality of Life index, higher post-traumatic stress disorder (PTSD) score, and a worse executive function performance in nonICU participants. Higher PTSD and Beck Depression Inventory scores correlated with lower executive performance. The same group showed a reorganization of spindle cortical generators.
Conclusions: Our results show executive and psycho-affective deficits and spindle alterations in COVID-19 survivors - especially in nonICU participants - after 12 months from discharge.
Significance: These findings may be suggestive of a crucial contribution of stress experienced during hospital admission on long-term cognitive functioning.
Keywords: Electroencephalography; Nap; Neuropsychological assessment; long COVID-19.
. 2022 Jun 15;140:126-135.
doi: 10.1016/j.clinph.2022.05.017. Online ahead of print.
High-density EEG sleep correlates of cognitive and affective impairment at 12-month follow-up after COVID-19
Maria Rubega[SUP] 1 [/SUP], Luciana Ciringione[SUP] 2 [/SUP], Margherita Bertuccelli[SUP] 3 [/SUP], Matilde Paramento[SUP] 4 [/SUP], Giovanni Sparacino[SUP] 5 [/SUP], Andrea Vianello[SUP] 6 [/SUP], Stefano Masiero[SUP] 7 [/SUP], Antonino Vallesi[SUP] 8 [/SUP], Emanuela Formaggio[SUP] 9 [/SUP], Alessandra Del Felice[SUP] 10 [/SUP]
Affiliations
- PMID: 35763985
- DOI: 10.1016/j.clinph.2022.05.017
Abstract
Objective: To disentangle the pathophysiology of cognitive/affective impairment in Coronavirus Disease-2019 (COVID-19), we studied long-term cognitive and affective sequelae and sleep high-density electroencephalography (EEG) at 12-month follow-up in people with a previous hospital admission for acute COVID-19.
Methods: People discharged from an intensive care unit (ICU) and a sub-intensive ward (nonICU) between March and May 2020 were contacted between March and June 2021. Participants underwent cognitive, psychological, and sleep assessment. High-density EEG recording was acquired during a nap. Slow and fast spindles density/amplitude/frequency and source reconstruction in brain gray matter were extracted. The relationship between psychological and cognitive findings was explored with Pearson correlation.
Results: We enrolled 33 participants ( 17 nonICU) and 12 controls. We observed a lower Physical Quality of Life index, higher post-traumatic stress disorder (PTSD) score, and a worse executive function performance in nonICU participants. Higher PTSD and Beck Depression Inventory scores correlated with lower executive performance. The same group showed a reorganization of spindle cortical generators.
Conclusions: Our results show executive and psycho-affective deficits and spindle alterations in COVID-19 survivors - especially in nonICU participants - after 12 months from discharge.
Significance: These findings may be suggestive of a crucial contribution of stress experienced during hospital admission on long-term cognitive functioning.
Keywords: Electroencephalography; Nap; Neuropsychological assessment; long COVID-19.
