tetano
Editor, Senior Moderator
Clin Microbiol Infect. 2020 Apr 15. pii: S1198-743X(20)30217-2. doi: 10.1016/j.cmi.2020.04.012. [Epub ahead of print]
Risk factors for disease severity, unimprovement, and mortality of COVID-19 patients in Wuhan, China.
Zhang J[SUP]1[/SUP], Wang X[SUP]2[/SUP], Jia X[SUP]1[/SUP], Li J[SUP]1[/SUP], Hu K[SUP]3[/SUP], Chen G[SUP]3[/SUP], Wei J[SUP]4[/SUP], Gong Z[SUP]5[/SUP], Zhou C[SUP]6[/SUP], Yu H[SUP]1[/SUP], Yu M[SUP]2[/SUP], Lei H[SUP]7[/SUP], Cheng F[SUP]8[/SUP], Zhang B[SUP]9[/SUP], Xu Y[SUP]10[/SUP], Wang G[SUP]11[/SUP], Dong W[SUP]12[/SUP].
Author information
Abstract
OBJECTIVE:
Since December 2019, coronavirus disease (COVID-19) emerged in Wuhan. However, the characteristics and risk factors associated with disease severity, unimprovement and mortality are unclear.
METHODS:
All consecutive patients diagnosed with COVID-19 admitted to the Renmin Hospital of Wuhan University from January 11 to February 6, 2020 were enrolled in this retrospective cohort study.
RESULTS:
A total of 663 COVID-19 patients were included in this study. Among those, 247 (37.3%) had at least one kind of chronic disease. A total of 0.5% (n=3) of patients were diagnosed with mild COVID-19, while 37.8% (251/663), 47.5% (315/663), and 14.2% (94/663) were in moderate, severe, and critical condition, respectively. In our hospital during follow-up, 251 of 663 (37.9%) patients were improved and 25 patients died, leading to a mortality rate of 3.77%. Older patients (>60 years old) and those with chronic diseases were prone to have severe and critical COVID-19 conditions, show unimprovement, and die (P < 0.001, < 0.001). Multivariate logistic regression analysis identified being male (OR = 0.486, 95% CI 0.311-0.758; P = 0.001), having severe COVID-19 conditions (OR = 0.129, 95% CI 0.082-0.201; P < 0.001), expectoration (OR = 1.796, 95% CI 1.062-3.036; P = 0.029), muscle ache (OR = 0.309, 95% CI 0.153-0.626; P = 0.001), and decreased albumin (OR = 1.929, 95% CI 1.199-3.104; P = 0.007) were associated with unimprovement in COVID-19 patients.
CONCLUSION:
Being male, in severe COVID-19 conditions, expectoration, muscle ache, and decreased albumin were independent risk factors which influence the improvement of COVID-19 patients.
Copyright ? 2020 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
PMID:32304745DOI:10.1016/j.cmi.2020.04.012
Risk factors for disease severity, unimprovement, and mortality of COVID-19 patients in Wuhan, China.
Zhang J[SUP]1[/SUP], Wang X[SUP]2[/SUP], Jia X[SUP]1[/SUP], Li J[SUP]1[/SUP], Hu K[SUP]3[/SUP], Chen G[SUP]3[/SUP], Wei J[SUP]4[/SUP], Gong Z[SUP]5[/SUP], Zhou C[SUP]6[/SUP], Yu H[SUP]1[/SUP], Yu M[SUP]2[/SUP], Lei H[SUP]7[/SUP], Cheng F[SUP]8[/SUP], Zhang B[SUP]9[/SUP], Xu Y[SUP]10[/SUP], Wang G[SUP]11[/SUP], Dong W[SUP]12[/SUP].
Author information
Abstract
OBJECTIVE:
Since December 2019, coronavirus disease (COVID-19) emerged in Wuhan. However, the characteristics and risk factors associated with disease severity, unimprovement and mortality are unclear.
METHODS:
All consecutive patients diagnosed with COVID-19 admitted to the Renmin Hospital of Wuhan University from January 11 to February 6, 2020 were enrolled in this retrospective cohort study.
RESULTS:
A total of 663 COVID-19 patients were included in this study. Among those, 247 (37.3%) had at least one kind of chronic disease. A total of 0.5% (n=3) of patients were diagnosed with mild COVID-19, while 37.8% (251/663), 47.5% (315/663), and 14.2% (94/663) were in moderate, severe, and critical condition, respectively. In our hospital during follow-up, 251 of 663 (37.9%) patients were improved and 25 patients died, leading to a mortality rate of 3.77%. Older patients (>60 years old) and those with chronic diseases were prone to have severe and critical COVID-19 conditions, show unimprovement, and die (P < 0.001, < 0.001). Multivariate logistic regression analysis identified being male (OR = 0.486, 95% CI 0.311-0.758; P = 0.001), having severe COVID-19 conditions (OR = 0.129, 95% CI 0.082-0.201; P < 0.001), expectoration (OR = 1.796, 95% CI 1.062-3.036; P = 0.029), muscle ache (OR = 0.309, 95% CI 0.153-0.626; P = 0.001), and decreased albumin (OR = 1.929, 95% CI 1.199-3.104; P = 0.007) were associated with unimprovement in COVID-19 patients.
CONCLUSION:
Being male, in severe COVID-19 conditions, expectoration, muscle ache, and decreased albumin were independent risk factors which influence the improvement of COVID-19 patients.
Copyright ? 2020 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
PMID:32304745DOI:10.1016/j.cmi.2020.04.012