tetano
Editor, Senior Moderator
Clin Microbiol Infect
. 2022 Sep 20;S1198-743X(22)00475-X.
doi: 10.1016/j.cmi.2022.09.007. Online ahead of print.
Association between low response to rubella vaccination and reduced anti-SARS-CoV-2 immune response after vaccination with BNT162b2: A cross-sectional study
Kazuhiko Nakaharai[SUP] 1 [/SUP], Yasushi Nakazawa[SUP] 2 [/SUP], Yukie Mishima[SUP] 3 [/SUP], Mari Saito[SUP] 3 [/SUP], Yoichi Shinozaki[SUP] 3 [/SUP], Masaki Yoshida[SUP] 4 [/SUP]
Affiliations
Abstract
Objectives: Some vaccinated individuals fail to acquire an adequate immune response against infection. We aimed to determine whether messenger-RNA severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination could induce sufficient immune response against SARS-CoV-2 in low responders to other vaccinations.
Methods: Using data from healthcare workers who received two doses of the BNT162b2 vaccine (BioNTech, Pfizer), we conducted a single-centre cross-sectional study to determine whether low responders to measles, rubella, and hepatitis B virus (HBV) vaccinations could acquire sufficient antibodies after SARS-CoV-2 vaccination. From May 2021 to June 2021, participants were tested for anti-SARS-CoV-2 spike immunoglobulin G (anti-S IgG) antibody at least two weeks after the second dose of BNT162b2. The association between low response to measles, rubella, and HBV vaccinations and the post-vaccination anti-S IgG titre was evaluated using multivariable linear regression analysis.
Results: All 714 participants were positive for the anti-S IgG titre (≥50.0 AU/mL) after two doses of BNT162b2 (median: 7,126.8 AU/mL, interquartile range: 4,496.2-11,296.8). There were 323 (45.2%), 131 (18.3%), and 43 (6.0%) low responders to measles, rubella, and HBV vaccinations, respectively. In the multivariable linear regression analysis, low responders to rubella vaccination had a significantly low acquisition of anti-S IgG titre after two doses of the BNT162b2 vaccine (standardised coefficient β = -0.110: 95% confidence interval: -0.175 to -0.044).
Conclusions: Low response to rubella vaccination is a potential predictor of reduced response to SARS-CoV-2 vaccination. Further studies are needed to determine whether a low response to rubella vaccination is associated with the durability of SARS-CoV-2 vaccination-induced immune response.
Keywords: Antibody; BNT162b2; COVID-19; SARS-CoV-2; Vaccine; rubella.
. 2022 Sep 20;S1198-743X(22)00475-X.
doi: 10.1016/j.cmi.2022.09.007. Online ahead of print.
Association between low response to rubella vaccination and reduced anti-SARS-CoV-2 immune response after vaccination with BNT162b2: A cross-sectional study
Kazuhiko Nakaharai[SUP] 1 [/SUP], Yasushi Nakazawa[SUP] 2 [/SUP], Yukie Mishima[SUP] 3 [/SUP], Mari Saito[SUP] 3 [/SUP], Yoichi Shinozaki[SUP] 3 [/SUP], Masaki Yoshida[SUP] 4 [/SUP]
Affiliations
- PMID: 36150670
- PMCID: PMC9485426
- DOI: 10.1016/j.cmi.2022.09.007
Abstract
Objectives: Some vaccinated individuals fail to acquire an adequate immune response against infection. We aimed to determine whether messenger-RNA severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination could induce sufficient immune response against SARS-CoV-2 in low responders to other vaccinations.
Methods: Using data from healthcare workers who received two doses of the BNT162b2 vaccine (BioNTech, Pfizer), we conducted a single-centre cross-sectional study to determine whether low responders to measles, rubella, and hepatitis B virus (HBV) vaccinations could acquire sufficient antibodies after SARS-CoV-2 vaccination. From May 2021 to June 2021, participants were tested for anti-SARS-CoV-2 spike immunoglobulin G (anti-S IgG) antibody at least two weeks after the second dose of BNT162b2. The association between low response to measles, rubella, and HBV vaccinations and the post-vaccination anti-S IgG titre was evaluated using multivariable linear regression analysis.
Results: All 714 participants were positive for the anti-S IgG titre (≥50.0 AU/mL) after two doses of BNT162b2 (median: 7,126.8 AU/mL, interquartile range: 4,496.2-11,296.8). There were 323 (45.2%), 131 (18.3%), and 43 (6.0%) low responders to measles, rubella, and HBV vaccinations, respectively. In the multivariable linear regression analysis, low responders to rubella vaccination had a significantly low acquisition of anti-S IgG titre after two doses of the BNT162b2 vaccine (standardised coefficient β = -0.110: 95% confidence interval: -0.175 to -0.044).
Conclusions: Low response to rubella vaccination is a potential predictor of reduced response to SARS-CoV-2 vaccination. Further studies are needed to determine whether a low response to rubella vaccination is associated with the durability of SARS-CoV-2 vaccination-induced immune response.
Keywords: Antibody; BNT162b2; COVID-19; SARS-CoV-2; Vaccine; rubella.