tetano
Editor, Senior Moderator
Clin Lymphoma Myeloma Leuk
. 2022 Oct;22 Suppl 2:S383-S384.
doi: 10.1016/S2152-2650(22)01548-8.
IBCL-054 The Effects of an mRNA COVID-19 Vaccine Booster on Immune Responses in Cancer-Bearing Veterans
Arthur Frankel[SUP] 1 [/SUP], Tazio Capozzola[SUP] 2 [/SUP], Raiees Andrabi[SUP] 2 [/SUP], Chul Ahn[SUP] 3 [/SUP], Dennis Burton[SUP] 2 [/SUP]
Affiliations
Abstract
Serum antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein are surrogate markers of immune response. We evaluated antibody levels pre and post third vaccine (booster) and compared responses among different cancer-bearing and normal veterans. Both total and neutralizing antibody levels increased in most subjects after the booster, but the frequency and magnitude of responses were lower in patients with B-cell malignancies undergoing therapy. Neutralizing antibody responses to omicron variants were reduced relative to wild-type and other variants. Additional prevention and prophylactic measures are warranted for poor vaccine responders.
Keywords: B-cell malignancies; IBCL; antibodies; cancer; coronavirus; vaccine.
. 2022 Oct;22 Suppl 2:S383-S384.
doi: 10.1016/S2152-2650(22)01548-8.
IBCL-054 The Effects of an mRNA COVID-19 Vaccine Booster on Immune Responses in Cancer-Bearing Veterans
Arthur Frankel[SUP] 1 [/SUP], Tazio Capozzola[SUP] 2 [/SUP], Raiees Andrabi[SUP] 2 [/SUP], Chul Ahn[SUP] 3 [/SUP], Dennis Burton[SUP] 2 [/SUP]
Affiliations
- PMID: 36164097
- DOI: 10.1016/S2152-2650(22)01548-8
Abstract
Serum antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein are surrogate markers of immune response. We evaluated antibody levels pre and post third vaccine (booster) and compared responses among different cancer-bearing and normal veterans. Both total and neutralizing antibody levels increased in most subjects after the booster, but the frequency and magnitude of responses were lower in patients with B-cell malignancies undergoing therapy. Neutralizing antibody responses to omicron variants were reduced relative to wild-type and other variants. Additional prevention and prophylactic measures are warranted for poor vaccine responders.
Keywords: B-cell malignancies; IBCL; antibodies; cancer; coronavirus; vaccine.