tetano
Editor, Senior Moderator
Clin Lab Med
. 2022 Mar;42(1):75-84.
doi: 10.1016/j.cll.2021.10.001. Epub 2021 Nov 3.
Suboptimal Humoral Immunity in Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Viral Variant Generation
Shiv Pillai[SUP] 1 [/SUP]
Affiliations
Abstract
This review describes the underlying basis for the sup-optimal humoral immune response in coronavirus disease (COVID)-19 including the absence of evidence for affinity maturation in the vast majority of patients and the absence of germinal centers even in severe disease. Suboptimal humoral and cellular immunity may provide the optimal conditions for the generation and selection of viral variants.
Keywords: COVID-19; Germinal centers; Humoral immunity; Immune pressure; SARS-CoV-2; T follicular helper cells; Variant generation.
. 2022 Mar;42(1):75-84.
doi: 10.1016/j.cll.2021.10.001. Epub 2021 Nov 3.
Suboptimal Humoral Immunity in Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Viral Variant Generation
Shiv Pillai[SUP] 1 [/SUP]
Affiliations
- PMID: 35153049
- DOI: 10.1016/j.cll.2021.10.001
Abstract
This review describes the underlying basis for the sup-optimal humoral immune response in coronavirus disease (COVID)-19 including the absence of evidence for affinity maturation in the vast majority of patients and the absence of germinal centers even in severe disease. Suboptimal humoral and cellular immunity may provide the optimal conditions for the generation and selection of viral variants.
Keywords: COVID-19; Germinal centers; Humoral immunity; Immune pressure; SARS-CoV-2; T follicular helper cells; Variant generation.