tetano
Editor, Senior Moderator
Clin Lab Med
. 2022 Mar;42(1):97-109.
doi: 10.1016/j.cll.2021.10.002. Epub 2021 Nov 3.
Severe Acute Respiratory Syndrome Coronavirus 2 Antigens as Targets of Antibody Responses
Alana F Ogata[SUP] 1 [/SUP], Roey Lazarovits[SUP] 2 [/SUP], Augusta Uwamanzu-Nna[SUP] 3 [/SUP], Tal Gilboa[SUP] 1 [/SUP], Chi-An Cheng[SUP] 1 [/SUP], David R Walt[SUP] 4 [/SUP]
Affiliations
Abstract
Humoral immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during acute infection and convalescence has been widely studied since March 2020. In this review, the authors summarize literature on humoral responses to SARS-CoV-2 antigens with a focus on spike, nucleocapsid, and the receptor-binding domain as targets of antibody responses. They highlight serologic studies during acute SARS-CoV-2 infection and discuss the clinical relevance of antibody levels in COVID-19 progression. Antibody responses in pediatric COVID-19 patients are also reviewed. Finally, the authors discuss antibody responses during convalescence and their role in protection from SARS-CoV-2 reinfection.
Keywords: Antigen-antibody responses; Coronavirus antigens; Humoral immunity; SARS-CoV-2.
. 2022 Mar;42(1):97-109.
doi: 10.1016/j.cll.2021.10.002. Epub 2021 Nov 3.
Severe Acute Respiratory Syndrome Coronavirus 2 Antigens as Targets of Antibody Responses
Alana F Ogata[SUP] 1 [/SUP], Roey Lazarovits[SUP] 2 [/SUP], Augusta Uwamanzu-Nna[SUP] 3 [/SUP], Tal Gilboa[SUP] 1 [/SUP], Chi-An Cheng[SUP] 1 [/SUP], David R Walt[SUP] 4 [/SUP]
Affiliations
- PMID: 35153051
- DOI: 10.1016/j.cll.2021.10.002
Abstract
Humoral immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during acute infection and convalescence has been widely studied since March 2020. In this review, the authors summarize literature on humoral responses to SARS-CoV-2 antigens with a focus on spike, nucleocapsid, and the receptor-binding domain as targets of antibody responses. They highlight serologic studies during acute SARS-CoV-2 infection and discuss the clinical relevance of antibody levels in COVID-19 progression. Antibody responses in pediatric COVID-19 patients are also reviewed. Finally, the authors discuss antibody responses during convalescence and their role in protection from SARS-CoV-2 reinfection.
Keywords: Antigen-antibody responses; Coronavirus antigens; Humoral immunity; SARS-CoV-2.