tetano
Editor, Senior Moderator
Clin Lab Med
. 2025 Dec;45(4):643-655.
doi: 10.1016/j.cll.2025.07.008. Epub 2025 Aug 11. Hemostatic Disorders Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection, COVID-19 Vaccination, and Long-COVID Syndrome: Current Evidence and Controversies in Clinical Practice
Prakash Vishnu[SUP] 1 [/SUP], David M Aboulafia[SUP] 2 [/SUP]
Affiliations
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has presented profound global health challenges. Beyond acute illness, a substantial proportion of individuals experience persistent symptoms including fatigue, brain fog, and post-exertional malaise, collectively known as Long-COVID. Among the complications associated with SARS-CoV-2 infection and vaccination, hemostatic disorders ranging from mild platelet dysfunction to severe thromboembolic events, and rare but serious coagulation-related adverse effects, such as vaccine-induced immune thrombotic thrombocytopenia, have emerged as a significant concern. Herein we provide an overview of current information and controversies surrounding hemostatic complications in SARS-CoV-2 infection and COVID-19 vaccination.
Keywords: COVID-19 vaccine; Severe acute respiratory syndrome coronavirus 2 infection; Thrombosis; Vaccine-induced thrombotic thrombocytopenia.
. 2025 Dec;45(4):643-655.
doi: 10.1016/j.cll.2025.07.008. Epub 2025 Aug 11. Hemostatic Disorders Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection, COVID-19 Vaccination, and Long-COVID Syndrome: Current Evidence and Controversies in Clinical Practice
Prakash Vishnu[SUP] 1 [/SUP], David M Aboulafia[SUP] 2 [/SUP]
Affiliations
- PMID: 41161981
- DOI: 10.1016/j.cll.2025.07.008
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has presented profound global health challenges. Beyond acute illness, a substantial proportion of individuals experience persistent symptoms including fatigue, brain fog, and post-exertional malaise, collectively known as Long-COVID. Among the complications associated with SARS-CoV-2 infection and vaccination, hemostatic disorders ranging from mild platelet dysfunction to severe thromboembolic events, and rare but serious coagulation-related adverse effects, such as vaccine-induced immune thrombotic thrombocytopenia, have emerged as a significant concern. Herein we provide an overview of current information and controversies surrounding hemostatic complications in SARS-CoV-2 infection and COVID-19 vaccination.
Keywords: COVID-19 vaccine; Severe acute respiratory syndrome coronavirus 2 infection; Thrombosis; Vaccine-induced thrombotic thrombocytopenia.