tetano
Editor, Senior Moderator
Clin Kidney J
. 2020 Dec 14;13(6):1101-1104.
doi: 10.1093/ckj/sfaa209. eCollection 2020 Dec.
Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures
Mathilde Dargelos[SUP] 1 [/SUP], Aymeric Couturier[SUP] 1 2 [/SUP], Sophie Ferlicot[SUP] 3 [/SUP], Jean-Michel Goujon[SUP] 4 [/SUP], Anne-Marie Roque-Afonso[SUP] 5 6 [/SUP], Elyanne Gault[SUP] 7 [/SUP], Guy Touchard[SUP] 4 8 [/SUP], Cecile Ory[SUP] 4 [/SUP], Sihem Kaaki[SUP] 4 [/SUP], Eve Vilaine[SUP] 1 [/SUP], Marie Essig[SUP] 1 2 [/SUP], Ziad A Massy[SUP] 1 2 [/SUP]
Affiliations
Abstract
Background: The objectives were to characterize Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) in patients with acute kidney injury (AKI).
Methods: Kidney biopsy samples in two Caucasian patients and one African with COVID-19 AKI were investigated.
Results: All patients had a high-level non-selective glomerular proteinuria. SARS-CoV-2 samples by real-time polymerase chain reaction (RT- PCR) assay were all-negative, as well as for virus particles in the kidney by electron microscopy. The three patients and patients with other AKI did not differ significantly with regard to angiotensin-converting enzyme 2 and transmembrane protease serine 2 kidney staining.
Conclusions: The kidney damage particularly in Caucasians in COVID-19 seems to be an AKI, possibly by the systemic inflammatory response.
Keywords: SARS-CoV-2; COVID-19; Caucasian patient; angiotensin-converting enzyme 2; electron microscopy; kidney disease; tubular proteinuria.
. 2020 Dec 14;13(6):1101-1104.
doi: 10.1093/ckj/sfaa209. eCollection 2020 Dec.
Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures
Mathilde Dargelos[SUP] 1 [/SUP], Aymeric Couturier[SUP] 1 2 [/SUP], Sophie Ferlicot[SUP] 3 [/SUP], Jean-Michel Goujon[SUP] 4 [/SUP], Anne-Marie Roque-Afonso[SUP] 5 6 [/SUP], Elyanne Gault[SUP] 7 [/SUP], Guy Touchard[SUP] 4 8 [/SUP], Cecile Ory[SUP] 4 [/SUP], Sihem Kaaki[SUP] 4 [/SUP], Eve Vilaine[SUP] 1 [/SUP], Marie Essig[SUP] 1 2 [/SUP], Ziad A Massy[SUP] 1 2 [/SUP]
Affiliations
- PMID: 33391755
- PMCID: PMC7769537
- DOI: 10.1093/ckj/sfaa209
Abstract
Background: The objectives were to characterize Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) in patients with acute kidney injury (AKI).
Methods: Kidney biopsy samples in two Caucasian patients and one African with COVID-19 AKI were investigated.
Results: All patients had a high-level non-selective glomerular proteinuria. SARS-CoV-2 samples by real-time polymerase chain reaction (RT- PCR) assay were all-negative, as well as for virus particles in the kidney by electron microscopy. The three patients and patients with other AKI did not differ significantly with regard to angiotensin-converting enzyme 2 and transmembrane protease serine 2 kidney staining.
Conclusions: The kidney damage particularly in Caucasians in COVID-19 seems to be an AKI, possibly by the systemic inflammatory response.
Keywords: SARS-CoV-2; COVID-19; Caucasian patient; angiotensin-converting enzyme 2; electron microscopy; kidney disease; tubular proteinuria.