tetano
Editor, Senior Moderator
Clin Kidney J
. 2021 Sep 27;15(2):262-268.
doi: 10.1093/ckj/sfab166. eCollection 2022 Feb.
Long-term impact of COVID-19 among maintenance haemodialysis patients
Sylvain Chawki[SUP] 1 [/SUP], Albert Buchard[SUP] 2 [/SUP], Hamza Sakhi[SUP] 3 4 [/SUP], Karim Dardim[SUP] 5 [/SUP], Karim El Sakhawi[SUP] 3 [/SUP], Mokhtar Chawki[SUP] 6 [/SUP], Henri Boulanger[SUP] 7 [/SUP], Tomek Kofman[SUP] 8 [/SUP], Djamal Dahmane[SUP] 3 4 [/SUP], Philippe Rieu[SUP] 9 [/SUP], David Attaf[SUP] 10 [/SUP], Salima Ahriz-Saksi[SUP] 7 [/SUP], Afshin Masoumi[SUP] 8 [/SUP], Ali Zineddine Diddaoui[SUP] 6 [/SUP], Luc Fromentin[SUP] 6 [/SUP], Patrick Michaut[SUP] 11 [/SUP], Rachida Nebbad[SUP] 12 [/SUP], Jean-François Desassis[SUP] 13 [/SUP], Laurence Nicolet[SUP] 13 [/SUP], Julie Sohier-Attias[SUP] 14 [/SUP], Frederic Besson[SUP] 15 [/SUP], Remy Boula[SUP] 15 [/SUP], Ali Hafi[SUP] 15 [/SUP], Abderrahmane Ghazali[SUP] 16 [/SUP], Larbi Lamriben[SUP] 17 [/SUP], Adem Arezki[SUP] 17 [/SUP], Emmanuel Dupuis[SUP] 18 [/SUP], Mohamad-Khair Rifard[SUP] 19 [/SUP], Dominique Joly[SUP] 20 [/SUP], Philippe Attias[SUP] 9 [/SUP], Khalil El Karoui[SUP] 3 4 [/SUP]
Affiliations
Abstract
Background: Maintenance haemodialysis (MHD) patients have a high risk of initial mortality from coronavirus disease 2019 (COVID-19). However, long-term consequences of this disease in the MHD population are poorly described. We report the clinical presentation, outcome and long-term follow-up of MHD patients affected by COVID-19 in a multicentric cohort from the Paris, France area.
Methods: We conducted a retrospective analysis of clinical presentation and long-term follow-up of MHD patients affected by COVID-19 in 19 MHD centres in the Paris, France area.
Results: In this cohort of 248 patients with an initial mortality rate of 18%, age, comorbidities, dyspnoea and previous immunosuppressive treatment were associated with death at <30 days. Among the 203 surviving patients following the acute phase, long-term follow-up (median 180 days) was available for 189 (93%) patients. Major adverse events occurred in 30 (16%) patients during follow-up, including 12 deaths (6%) after a median of 78 days from onset of symptoms. Overall, cardiovascular events, infections and gastrointestinal bleeding were the main major adverse events. Post-COVID-19 cachexia was observed in 25/189 (13%) patients. Lower initial albuminaemia was significantly associated with this cachexia. No reinfection with severe acute respiratory syndrome coronavirus 2 was observed.
Conclusions: This work demonstrates the long-term consequences of COVID-19 in MHD patients, highlighting both initial and long-term severity of the disease, including severe cachexia.
Keywords: COVID-19; SARS-CoV-2; cachexia; haemodialysis; long-term follow-up; mortality; nutritional status.
. 2021 Sep 27;15(2):262-268.
doi: 10.1093/ckj/sfab166. eCollection 2022 Feb.
Long-term impact of COVID-19 among maintenance haemodialysis patients
Sylvain Chawki[SUP] 1 [/SUP], Albert Buchard[SUP] 2 [/SUP], Hamza Sakhi[SUP] 3 4 [/SUP], Karim Dardim[SUP] 5 [/SUP], Karim El Sakhawi[SUP] 3 [/SUP], Mokhtar Chawki[SUP] 6 [/SUP], Henri Boulanger[SUP] 7 [/SUP], Tomek Kofman[SUP] 8 [/SUP], Djamal Dahmane[SUP] 3 4 [/SUP], Philippe Rieu[SUP] 9 [/SUP], David Attaf[SUP] 10 [/SUP], Salima Ahriz-Saksi[SUP] 7 [/SUP], Afshin Masoumi[SUP] 8 [/SUP], Ali Zineddine Diddaoui[SUP] 6 [/SUP], Luc Fromentin[SUP] 6 [/SUP], Patrick Michaut[SUP] 11 [/SUP], Rachida Nebbad[SUP] 12 [/SUP], Jean-François Desassis[SUP] 13 [/SUP], Laurence Nicolet[SUP] 13 [/SUP], Julie Sohier-Attias[SUP] 14 [/SUP], Frederic Besson[SUP] 15 [/SUP], Remy Boula[SUP] 15 [/SUP], Ali Hafi[SUP] 15 [/SUP], Abderrahmane Ghazali[SUP] 16 [/SUP], Larbi Lamriben[SUP] 17 [/SUP], Adem Arezki[SUP] 17 [/SUP], Emmanuel Dupuis[SUP] 18 [/SUP], Mohamad-Khair Rifard[SUP] 19 [/SUP], Dominique Joly[SUP] 20 [/SUP], Philippe Attias[SUP] 9 [/SUP], Khalil El Karoui[SUP] 3 4 [/SUP]
Affiliations
- PMID: 35140935
- PMCID: PMC8522382
- DOI: 10.1093/ckj/sfab166
Abstract
Background: Maintenance haemodialysis (MHD) patients have a high risk of initial mortality from coronavirus disease 2019 (COVID-19). However, long-term consequences of this disease in the MHD population are poorly described. We report the clinical presentation, outcome and long-term follow-up of MHD patients affected by COVID-19 in a multicentric cohort from the Paris, France area.
Methods: We conducted a retrospective analysis of clinical presentation and long-term follow-up of MHD patients affected by COVID-19 in 19 MHD centres in the Paris, France area.
Results: In this cohort of 248 patients with an initial mortality rate of 18%, age, comorbidities, dyspnoea and previous immunosuppressive treatment were associated with death at <30 days. Among the 203 surviving patients following the acute phase, long-term follow-up (median 180 days) was available for 189 (93%) patients. Major adverse events occurred in 30 (16%) patients during follow-up, including 12 deaths (6%) after a median of 78 days from onset of symptoms. Overall, cardiovascular events, infections and gastrointestinal bleeding were the main major adverse events. Post-COVID-19 cachexia was observed in 25/189 (13%) patients. Lower initial albuminaemia was significantly associated with this cachexia. No reinfection with severe acute respiratory syndrome coronavirus 2 was observed.
Conclusions: This work demonstrates the long-term consequences of COVID-19 in MHD patients, highlighting both initial and long-term severity of the disease, including severe cachexia.
Keywords: COVID-19; SARS-CoV-2; cachexia; haemodialysis; long-term follow-up; mortality; nutritional status.