tetano
Editor, Senior Moderator
Clin Kidney J
. 2022 Oct 19;15(12):2340-2342.
doi: 10.1093/ckj/sfac222. eCollection 2022 Dec.
Development of crescentic membranoproliferative glomerulonephritis after COVID-19 vaccination
Gabor Göndör[SUP] 1 [/SUP], Sara H Ksiazek[SUP] 1 [/SUP], Heinz Regele[SUP] 2 [/SUP], Andreas Kronbichler[SUP] 3 [/SUP], Maarten Knechtelsdorfer[SUP] 1 [/SUP], Marcus D Säemann[SUP] 1 4 [/SUP]
Affiliations
Abstract
Membranoproliferative glomerulonephritis (MPGN) comprises a histologic pattern of glomerular injury with different underlying diseases. Here we report on a 47-year-old female with rapidly progressive glomerulonephritis (RPGN) on top of a previously diagnosed idiopathic MPGN after receiving the first dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) mRNA vaccine. After aggressive immunosuppression her serum creatinine returned to normal values, along with reduction of proteinuria. Recently, numerous publications have reported an association of glomerular diseases with COVID-19 vaccination. Our case presents to the best of our knowledge the first occurrence of possible association of COVID-19 mRNA vaccination with a crescentic form of MPGN.
Keywords: AKI; COVID-19; membranoproliferative glomerulonephritis; nephrotic syndrome; vaccination.
. 2022 Oct 19;15(12):2340-2342.
doi: 10.1093/ckj/sfac222. eCollection 2022 Dec.
Development of crescentic membranoproliferative glomerulonephritis after COVID-19 vaccination
Gabor Göndör[SUP] 1 [/SUP], Sara H Ksiazek[SUP] 1 [/SUP], Heinz Regele[SUP] 2 [/SUP], Andreas Kronbichler[SUP] 3 [/SUP], Maarten Knechtelsdorfer[SUP] 1 [/SUP], Marcus D Säemann[SUP] 1 4 [/SUP]
Affiliations
- PMID: 36381369
- PMCID: PMC9619771
- DOI: 10.1093/ckj/sfac222
Abstract
Membranoproliferative glomerulonephritis (MPGN) comprises a histologic pattern of glomerular injury with different underlying diseases. Here we report on a 47-year-old female with rapidly progressive glomerulonephritis (RPGN) on top of a previously diagnosed idiopathic MPGN after receiving the first dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) mRNA vaccine. After aggressive immunosuppression her serum creatinine returned to normal values, along with reduction of proteinuria. Recently, numerous publications have reported an association of glomerular diseases with COVID-19 vaccination. Our case presents to the best of our knowledge the first occurrence of possible association of COVID-19 mRNA vaccination with a crescentic form of MPGN.
Keywords: AKI; COVID-19; membranoproliferative glomerulonephritis; nephrotic syndrome; vaccination.