tetano
Editor, Senior Moderator
Clin J Gastroenterol
. 2022 Jun 18.
doi: 10.1007/s12328-022-01654-0. Online ahead of print.
Autoimmune hepatitis with history of HCV treatment triggered by COVID-19 vaccination: case report and literature review
Naoyuki Hasegawa[SUP] 1 [/SUP], Ryota Matsuoka[SUP] 2 [/SUP], Naoki Ishikawa[SUP] 3 [/SUP], Masato Endo[SUP] 3 [/SUP], Masahiko Terasaki[SUP] 3 [/SUP], Emiko Seo[SUP] 3 [/SUP], Kiichiro Tsuchiya[SUP] 3 [/SUP]
Affiliations
Abstract
Although vaccines have been effective against the worldwide pandemic of Coronavirus Disease 19 (COVID-19), some case reports have described autoimmune hepatitis triggered by COVID-19 vaccination. Meanwhile, hepatitis C virus (HCV) is known to be related to autoimmune diseases. Here, we report a case of autoimmune hepatitis with history of HCV treatment triggered by COVID-19 vaccination. An 82-year-old woman was referred to our hospital for severe liver injury. She had received a COVID-19 vaccination 7 days prior. She had a history of HCV treatment with direct-acting antivirals 7 years previously. In her blood data, despite HCV antibody positivity, she was negative for HCV RNA by real-time RT-PCR. Anti-nuclear antibody was positive and IgG was elevated. Interface hepatitis and plasma cell infiltration were confirmed pathologically. She was diagnosed as autoimmune hepatitis and her liver injury quickly improved after initiation of steroid administration. This is a first case report of autoimmune hepatitis with history of HCV treatment triggered by COVID-19 vaccination.
Keywords: Autoimmune hepatitis; COVID-19; Hepatitis C; SARS-CoV-2; Vaccination.
. 2022 Jun 18.
doi: 10.1007/s12328-022-01654-0. Online ahead of print.
Autoimmune hepatitis with history of HCV treatment triggered by COVID-19 vaccination: case report and literature review
Naoyuki Hasegawa[SUP] 1 [/SUP], Ryota Matsuoka[SUP] 2 [/SUP], Naoki Ishikawa[SUP] 3 [/SUP], Masato Endo[SUP] 3 [/SUP], Masahiko Terasaki[SUP] 3 [/SUP], Emiko Seo[SUP] 3 [/SUP], Kiichiro Tsuchiya[SUP] 3 [/SUP]
Affiliations
- PMID: 35716255
- DOI: 10.1007/s12328-022-01654-0
Abstract
Although vaccines have been effective against the worldwide pandemic of Coronavirus Disease 19 (COVID-19), some case reports have described autoimmune hepatitis triggered by COVID-19 vaccination. Meanwhile, hepatitis C virus (HCV) is known to be related to autoimmune diseases. Here, we report a case of autoimmune hepatitis with history of HCV treatment triggered by COVID-19 vaccination. An 82-year-old woman was referred to our hospital for severe liver injury. She had received a COVID-19 vaccination 7 days prior. She had a history of HCV treatment with direct-acting antivirals 7 years previously. In her blood data, despite HCV antibody positivity, she was negative for HCV RNA by real-time RT-PCR. Anti-nuclear antibody was positive and IgG was elevated. Interface hepatitis and plasma cell infiltration were confirmed pathologically. She was diagnosed as autoimmune hepatitis and her liver injury quickly improved after initiation of steroid administration. This is a first case report of autoimmune hepatitis with history of HCV treatment triggered by COVID-19 vaccination.
Keywords: Autoimmune hepatitis; COVID-19; Hepatitis C; SARS-CoV-2; Vaccination.