tetano
Editor, Senior Moderator
Clin Infect Pract
. 2023 Jan;17:100219.
doi: 10.1016/j.clinpr.2023.100219. Epub 2023 Jan 18.
Fetal demise and SARS-CoV-2 infection during pregnancy: Histopathological and immunohistochemical findings of three cases referred to the Colombian National Institute of Health
Marcela Daza[SUP] 1 [/SUP], Sheryll Corchuelo[SUP] 2 [/SUP], Johana Osorio[SUP] 1 [/SUP], Luis Alberto Gómez[SUP] 3 [/SUP], Edgar Parra[SUP] 4 [/SUP], Ángela Alarcón[SUP] 5 [/SUP], Marcela Mercado[SUP] 6 [/SUP]
Affiliations
Abstract
Background: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection during pregnancy is related with adverse maternal, fetal, and neonatal outcomes. Placental SARS-CoV-2 involvement may include various degrees of inflammation and malperfusion leading to diverse pregnancy complications.
Methods: Placental, fetal and umbilical cord samples of three fetal demise cases that occurred in the context of maternal SARS-CoV-2 infections were analyzed. Cases were notified to the Colombian SARS-CoV-2 National Surveillance System. RT-PCR and immunohistochemistry (IHC) analysis were employed to identify potential tissue viral involvement.
Results: RT-PCR and IHC confirmed the presence of viral genomes and antigens in placental and umbilical cord tissues. Histopathological analysis revealed findings consistent with placental malperfusion and inflammation.
Conclusions: SARS-CoV-2 infection during pregnancy can lead to placental dysfunction and damage compromising fetal survival. Many questions regarding SARS-CoV-2 dynamics during pregnancy including placental physiopathology and in utero transmission are still pending definitive answers.
Keywords: Fetus; Pathology; Placenta; Pregnancy; SARS-CoV-2.
. 2023 Jan;17:100219.
doi: 10.1016/j.clinpr.2023.100219. Epub 2023 Jan 18.
Fetal demise and SARS-CoV-2 infection during pregnancy: Histopathological and immunohistochemical findings of three cases referred to the Colombian National Institute of Health
Marcela Daza[SUP] 1 [/SUP], Sheryll Corchuelo[SUP] 2 [/SUP], Johana Osorio[SUP] 1 [/SUP], Luis Alberto Gómez[SUP] 3 [/SUP], Edgar Parra[SUP] 4 [/SUP], Ángela Alarcón[SUP] 5 [/SUP], Marcela Mercado[SUP] 6 [/SUP]
Affiliations
- PMID: 36687140
- PMCID: PMC9846883
- DOI: 10.1016/j.clinpr.2023.100219
Abstract
Background: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection during pregnancy is related with adverse maternal, fetal, and neonatal outcomes. Placental SARS-CoV-2 involvement may include various degrees of inflammation and malperfusion leading to diverse pregnancy complications.
Methods: Placental, fetal and umbilical cord samples of three fetal demise cases that occurred in the context of maternal SARS-CoV-2 infections were analyzed. Cases were notified to the Colombian SARS-CoV-2 National Surveillance System. RT-PCR and immunohistochemistry (IHC) analysis were employed to identify potential tissue viral involvement.
Results: RT-PCR and IHC confirmed the presence of viral genomes and antigens in placental and umbilical cord tissues. Histopathological analysis revealed findings consistent with placental malperfusion and inflammation.
Conclusions: SARS-CoV-2 infection during pregnancy can lead to placental dysfunction and damage compromising fetal survival. Many questions regarding SARS-CoV-2 dynamics during pregnancy including placental physiopathology and in utero transmission are still pending definitive answers.
Keywords: Fetus; Pathology; Placenta; Pregnancy; SARS-CoV-2.