tetano
Editor, Senior Moderator
Clin Infect Dis
. 2020 Jun 4;ciaa711.
doi: 10.1093/cid/ciaa711. Online ahead of print.
The Natural History and Transmission Potential of Asymptomatic SARS-CoV-2 Infection
Nguyen Van Vinh Chau[SUP] 1 [/SUP], Vo Thanh Lam[SUP] 1 [/SUP], Nguyen Thanh Dung[SUP] 1 [/SUP], Lam Minh Yen[SUP] 2 [/SUP], Ngo Ngoc Quang Minh[SUP] 3 [/SUP], Le Manh ****[SUP] 1 [/SUP], Nghiem My Ngoc[SUP] 1 [/SUP], Nguyen Tri Dung[SUP] 4 [/SUP], Dinh Nguyen Huy Man[SUP] 1 [/SUP], Lam Anh Nguyet[SUP] 2 [/SUP], Le Thanh Hoang Nhat[SUP] 2 [/SUP], Le Nguyen Truc Nhu[SUP] 2 [/SUP], Nguyen Thi Han Ny[SUP] 2 [/SUP], Nguyen Thi Thu Hong[SUP] 2 [/SUP], Evelyne Kestelyn[SUP] 2 5 [/SUP], Nguyen Thi Phuong Dung[SUP] 2 [/SUP], Tran Chanh Xuan[SUP] 6 [/SUP], Tran Tinh Hien[SUP] 2 5 [/SUP], Nguyen Thanh Phong[SUP] 1 [/SUP], Tran Nguyen Hoang Tu[SUP] 1 [/SUP], Ronald B Geskus[SUP] 2 5 [/SUP], Tran Tan Thanh[SUP] 2 [/SUP], Nguyen Thanh Truong[SUP] 1 [/SUP], Nguyen Tan Binh[SUP] 7 [/SUP], Tang Chi Thuong[SUP] 7 [/SUP], Guy Thwaites[SUP] 2 5 [/SUP], Le Van Tan[SUP] 2 [/SUP], OUCRU COVID-19 research group
Affiliations
Abstract
Background: Little is known about the natural history of asymptomatic SARS-CoV-2 infection or its contribution to infection transmission.
Methods: We conducted a prospective study at a quarantine center for COVID-19 in Ho Chi Minh City, Vietnam. We enrolled quarantined people with RT-PCR-confirmed SARS-CoV-2 infection, collecting clinical data, travel and contact history, and saliva at enrolment and daily nasopharyngeal throat swabs (NTS) for RT-PCR testing. We compared the natural history and transmission potential of asymptomatic and symptomatic individuals.
Results: Between March 10th and April 4th, 2020, 14,000 quarantined people were tested for SARS-CoV-2; 49 were positive. Of these, 30 participated in the study: 13(43%) never had symptoms and 17(57%) were symptomatic. 17(57%) participants acquired their infection outside Vietnam. Compared with symptomatic individuals, asymptomatic people were less likely to have detectable SARS-CoV-2 in NTS samples collected at enrolment (8/13 (62%) vs. 17/17 (100%) P=0.02). SARS-CoV-2 RNA was detected in 20/27 (74%) available saliva; 7/11 (64%) in the asymptomatic and 13/16 (81%) in the symptomatic group (P=0.56). Analysis of the probability of RT-PCR positivity showed asymptomatic participants had faster viral clearance than symptomatic participants (P<0.001 for difference over first 19 days). This difference was most pronounced during the first week of follow-up. Two of the asymptomatic individuals appeared to transmit the infection to up to four contacts.
Conclusions: Asymptomatic SARS-CoV-2 infection is common and can be detected by analysis of saliva or NTS. NTS viral loads fall faster in asymptomatic individuals, but they appear able to transmit the virus to others.
Keywords: COVID-19; SARS-CoV-2; Vietnam; coronaviruses; pandemic.
. 2020 Jun 4;ciaa711.
doi: 10.1093/cid/ciaa711. Online ahead of print.
The Natural History and Transmission Potential of Asymptomatic SARS-CoV-2 Infection
Nguyen Van Vinh Chau[SUP] 1 [/SUP], Vo Thanh Lam[SUP] 1 [/SUP], Nguyen Thanh Dung[SUP] 1 [/SUP], Lam Minh Yen[SUP] 2 [/SUP], Ngo Ngoc Quang Minh[SUP] 3 [/SUP], Le Manh ****[SUP] 1 [/SUP], Nghiem My Ngoc[SUP] 1 [/SUP], Nguyen Tri Dung[SUP] 4 [/SUP], Dinh Nguyen Huy Man[SUP] 1 [/SUP], Lam Anh Nguyet[SUP] 2 [/SUP], Le Thanh Hoang Nhat[SUP] 2 [/SUP], Le Nguyen Truc Nhu[SUP] 2 [/SUP], Nguyen Thi Han Ny[SUP] 2 [/SUP], Nguyen Thi Thu Hong[SUP] 2 [/SUP], Evelyne Kestelyn[SUP] 2 5 [/SUP], Nguyen Thi Phuong Dung[SUP] 2 [/SUP], Tran Chanh Xuan[SUP] 6 [/SUP], Tran Tinh Hien[SUP] 2 5 [/SUP], Nguyen Thanh Phong[SUP] 1 [/SUP], Tran Nguyen Hoang Tu[SUP] 1 [/SUP], Ronald B Geskus[SUP] 2 5 [/SUP], Tran Tan Thanh[SUP] 2 [/SUP], Nguyen Thanh Truong[SUP] 1 [/SUP], Nguyen Tan Binh[SUP] 7 [/SUP], Tang Chi Thuong[SUP] 7 [/SUP], Guy Thwaites[SUP] 2 5 [/SUP], Le Van Tan[SUP] 2 [/SUP], OUCRU COVID-19 research group
Affiliations
- PMID: 32497212
- DOI: 10.1093/cid/ciaa711
Abstract
Background: Little is known about the natural history of asymptomatic SARS-CoV-2 infection or its contribution to infection transmission.
Methods: We conducted a prospective study at a quarantine center for COVID-19 in Ho Chi Minh City, Vietnam. We enrolled quarantined people with RT-PCR-confirmed SARS-CoV-2 infection, collecting clinical data, travel and contact history, and saliva at enrolment and daily nasopharyngeal throat swabs (NTS) for RT-PCR testing. We compared the natural history and transmission potential of asymptomatic and symptomatic individuals.
Results: Between March 10th and April 4th, 2020, 14,000 quarantined people were tested for SARS-CoV-2; 49 were positive. Of these, 30 participated in the study: 13(43%) never had symptoms and 17(57%) were symptomatic. 17(57%) participants acquired their infection outside Vietnam. Compared with symptomatic individuals, asymptomatic people were less likely to have detectable SARS-CoV-2 in NTS samples collected at enrolment (8/13 (62%) vs. 17/17 (100%) P=0.02). SARS-CoV-2 RNA was detected in 20/27 (74%) available saliva; 7/11 (64%) in the asymptomatic and 13/16 (81%) in the symptomatic group (P=0.56). Analysis of the probability of RT-PCR positivity showed asymptomatic participants had faster viral clearance than symptomatic participants (P<0.001 for difference over first 19 days). This difference was most pronounced during the first week of follow-up. Two of the asymptomatic individuals appeared to transmit the infection to up to four contacts.
Conclusions: Asymptomatic SARS-CoV-2 infection is common and can be detected by analysis of saliva or NTS. NTS viral loads fall faster in asymptomatic individuals, but they appear able to transmit the virus to others.
Keywords: COVID-19; SARS-CoV-2; Vietnam; coronaviruses; pandemic.