tetano
Editor, Senior Moderator
Clin Infect Dis
. 2022 Sep 26;ciac769.
doi: 10.1093/cid/ciac769. Online ahead of print.
Remdesivir resistance in transplant recipients with persistent COVID-19
John I Hogan[SUP] 1 [/SUP], Ralf Duerr[SUP] 2 [/SUP], Dacia Dimartino[SUP] 3 [/SUP], Christian Marier[SUP] 3 [/SUP], Sarah E Hochman[SUP] 4 [/SUP], Sapna Mehta[SUP] 4 [/SUP], Guiqing Wang[SUP] 5 [/SUP], Adriana Heguy[SUP] 5 [/SUP]
Affiliations
Abstract
New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications.
Keywords: Antiviral Resistance; Immunocompromise; Remdesivir; Rituximab; Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2); Solid Organ Transplant.
. 2022 Sep 26;ciac769.
doi: 10.1093/cid/ciac769. Online ahead of print.
Remdesivir resistance in transplant recipients with persistent COVID-19
John I Hogan[SUP] 1 [/SUP], Ralf Duerr[SUP] 2 [/SUP], Dacia Dimartino[SUP] 3 [/SUP], Christian Marier[SUP] 3 [/SUP], Sarah E Hochman[SUP] 4 [/SUP], Sapna Mehta[SUP] 4 [/SUP], Guiqing Wang[SUP] 5 [/SUP], Adriana Heguy[SUP] 5 [/SUP]
Affiliations
- PMID: 36156117
- DOI: 10.1093/cid/ciac769
Abstract
New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications.
Keywords: Antiviral Resistance; Immunocompromise; Remdesivir; Rituximab; Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2); Solid Organ Transplant.