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Clin Infect Dis . Occurrence and Timing of Subsequent Severe Acute Respiratory Syndrome Coronavirus 2 Reverse-transcription Polymerase Chain Reactio

tetano

Editor, Senior Moderator
Clin Infect Dis


. 2021 Jan 27;72(2):323-326.
doi: 10.1093/cid/ciaa722.
Occurrence and Timing of Subsequent Severe Acute Respiratory Syndrome Coronavirus 2 Reverse-transcription Polymerase Chain Reaction Positivity Among Initially Negative Patients


Dustin R Long[SUP] 1 [/SUP], Saurabh Gombar[SUP] 2 [/SUP], Catherine A Hogan[SUP] 2 3 [/SUP], Alexander L Greninger[SUP] 4 5 [/SUP], Vikas O'Reilly-Shah[SUP] 6 [/SUP], Chloe Bryson-Cahn[SUP] 7 [/SUP], Bryan Stevens[SUP] 2 3 [/SUP], Arjun Rustagi[SUP] 8 [/SUP], Keith R Jerome[SUP] 4 5 [/SUP], Christina S Kong[SUP] 2 [/SUP], James Zehnder[SUP] 2 [/SUP], Nigam H Shah[SUP] 9 [/SUP], Noel S Weiss[SUP] 10 [/SUP], Benjamin A Pinsky[SUP] 2 3 8 [/SUP], Jacob E Sunshine[SUP] 6 [/SUP]



Affiliations

Abstract

Using data for 20 912 patients from 2 large academic health systems, we analyzed the frequency of severe acute respiratory syndrome coronavirus 2 reverse-transcription polymerase chain reaction test discordance among individuals initially testing negative by nasopharyngeal swab who were retested on clinical grounds within 7 days. The frequency of subsequent positivity within this window was 3.5% and was similar across institutions.

Keywords: COVID-19; RT-PCR; SARS-CoV-2; nasopharyngeal; test characteristics.
 
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