tetano
Editor, Senior Moderator
Clin Infect Dis
. 2022 Apr 20;ciac310.
doi: 10.1093/cid/ciac310. Online ahead of print.
Observations and perspectives on adaptive immunity to SARS-CoV-2
Jennifer Dan[SUP] 1 2 [/SUP], Ricardo da Silva Antunes[SUP] 1 [/SUP], Alba Grifoni[SUP] 1 [/SUP], Daniela Weiskopf[SUP] 1 [/SUP], Shane Crotty[SUP] 1 2 [/SUP], Alessandro Sette[SUP] 1 2 [/SUP]
Affiliations
Abstract
Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic began 2 years ago, the scientific community has swiftly worked to understand the transmission, pathogenesis, and immune response of this virus to implement public health policies and ultimately project an end to the pandemic. In this perspective, we present our work identifying SARS-CoV-2 epitopes to quantify T-cell responses and review how T-cells may help protect against severe disease. We examine our prior studies which demonstrate durable humoral and cell-mediated memory in natural infection and vaccination. We discuss how SARS-CoV-2-specific T-cells from either natural infection or vaccination can recognize emerging variants of concern, suggesting that the currently approved vaccines may be sufficient. We also discuss how preexisting cross-reactive T-cells promote rapid development of immune memory to SARS-CoV-2. We finally posit how identifying SARS-CoV-2 epitopes can help us develop a pan-coronavirus vaccine to prepare for future pandemics.
Keywords: Immune memory; epitopes; preexisting cross-reactive; variants.
. 2022 Apr 20;ciac310.
doi: 10.1093/cid/ciac310. Online ahead of print.
Observations and perspectives on adaptive immunity to SARS-CoV-2
Jennifer Dan[SUP] 1 2 [/SUP], Ricardo da Silva Antunes[SUP] 1 [/SUP], Alba Grifoni[SUP] 1 [/SUP], Daniela Weiskopf[SUP] 1 [/SUP], Shane Crotty[SUP] 1 2 [/SUP], Alessandro Sette[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35441229
- DOI: 10.1093/cid/ciac310
Abstract
Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic began 2 years ago, the scientific community has swiftly worked to understand the transmission, pathogenesis, and immune response of this virus to implement public health policies and ultimately project an end to the pandemic. In this perspective, we present our work identifying SARS-CoV-2 epitopes to quantify T-cell responses and review how T-cells may help protect against severe disease. We examine our prior studies which demonstrate durable humoral and cell-mediated memory in natural infection and vaccination. We discuss how SARS-CoV-2-specific T-cells from either natural infection or vaccination can recognize emerging variants of concern, suggesting that the currently approved vaccines may be sufficient. We also discuss how preexisting cross-reactive T-cells promote rapid development of immune memory to SARS-CoV-2. We finally posit how identifying SARS-CoV-2 epitopes can help us develop a pan-coronavirus vaccine to prepare for future pandemics.
Keywords: Immune memory; epitopes; preexisting cross-reactive; variants.