tetano
Editor, Senior Moderator
Clin Infect Dis
. 2023 Dec 11:ciad764.
doi: 10.1093/cid/ciad764. Online ahead of print. Modeling the impacts of antiviral prophylaxis strategies in mitigating seasonal influenza outbreaks in nursing homes
Sinead E Morris[SUP] 1 [/SUP], Casey M Zipfel[SUP] 2 [/SUP], Komal Peer[SUP] 3 [/SUP], Zachary J Madewell[SUP] 4 [/SUP], Stephan Brenner[SUP] 5 [/SUP], Shikha Garg[SUP] 1 [/SUP], Prabasaj Paul[SUP] 2 [/SUP], Rachel B Slayton[SUP] 2 [/SUP], Matthew Biggerstaff[SUP] 1 [/SUP]
Affiliations
Background: Antiviral chemoprophylaxis is recommended for use during influenza outbreaks in nursing homes to prevent transmission and severe disease among non-ill residents. Centers for Disease Control and Prevention (CDC) guidance recommends prophylaxis be initiated for all non-ill residents once an influenza outbreak is detected and be continued for at least 14 days and until seven days after the last laboratory-confirmed influenza case is identified. However, not all facilities strictly adhere to this guidance and the impact of such partial adherence is not fully understood.
Methods: We developed a stochastic compartmental framework to model influenza transmission within an average-sized U.S. nursing home. We compared the number of symptomatic illnesses and hospitalizations under varying prophylaxis implementation strategies, in addition to different levels of prophylaxis uptake and adherence by residents and healthcare personnel (HCP).
Results: Prophylaxis implemented according to current guidance reduced total symptomatic illnesses and hospitalizations among residents by an average of 12% and 36%, respectively, compared with no prophylaxis. We did not find evidence that alternative implementations of prophylaxis were more effective: compared to full adoption of current guidance, partial adoption resulted in increased symptomatic illnesses and/or hospitalizations, and longer or earlier adoption offered no additional improvements. In addition, increasing uptake and adherence among nursing home residents was effective in reducing resident illnesses and hospitalizations, but increasing HCP uptake had minimal indirect impacts for residents.
Conclusions: The greatest benefits of influenza prophylaxis during nursing home outbreaks will likely be achieved through increasing uptake and adherence among residents and following current CDC guidance.
Keywords: antiviral; influenza; mathematical model; nursing home; prophylaxis.
. 2023 Dec 11:ciad764.
doi: 10.1093/cid/ciad764. Online ahead of print. Modeling the impacts of antiviral prophylaxis strategies in mitigating seasonal influenza outbreaks in nursing homes
Sinead E Morris[SUP] 1 [/SUP], Casey M Zipfel[SUP] 2 [/SUP], Komal Peer[SUP] 3 [/SUP], Zachary J Madewell[SUP] 4 [/SUP], Stephan Brenner[SUP] 5 [/SUP], Shikha Garg[SUP] 1 [/SUP], Prabasaj Paul[SUP] 2 [/SUP], Rachel B Slayton[SUP] 2 [/SUP], Matthew Biggerstaff[SUP] 1 [/SUP]
Affiliations
- PMID: 38072652
- DOI: 10.1093/cid/ciad764
Background: Antiviral chemoprophylaxis is recommended for use during influenza outbreaks in nursing homes to prevent transmission and severe disease among non-ill residents. Centers for Disease Control and Prevention (CDC) guidance recommends prophylaxis be initiated for all non-ill residents once an influenza outbreak is detected and be continued for at least 14 days and until seven days after the last laboratory-confirmed influenza case is identified. However, not all facilities strictly adhere to this guidance and the impact of such partial adherence is not fully understood.
Methods: We developed a stochastic compartmental framework to model influenza transmission within an average-sized U.S. nursing home. We compared the number of symptomatic illnesses and hospitalizations under varying prophylaxis implementation strategies, in addition to different levels of prophylaxis uptake and adherence by residents and healthcare personnel (HCP).
Results: Prophylaxis implemented according to current guidance reduced total symptomatic illnesses and hospitalizations among residents by an average of 12% and 36%, respectively, compared with no prophylaxis. We did not find evidence that alternative implementations of prophylaxis were more effective: compared to full adoption of current guidance, partial adoption resulted in increased symptomatic illnesses and/or hospitalizations, and longer or earlier adoption offered no additional improvements. In addition, increasing uptake and adherence among nursing home residents was effective in reducing resident illnesses and hospitalizations, but increasing HCP uptake had minimal indirect impacts for residents.
Conclusions: The greatest benefits of influenza prophylaxis during nursing home outbreaks will likely be achieved through increasing uptake and adherence among residents and following current CDC guidance.
Keywords: antiviral; influenza; mathematical model; nursing home; prophylaxis.