tetano
Editor, Senior Moderator
Clin Infect Dis
. 2022 Aug 12;ciac652.
doi: 10.1093/cid/ciac652. Online ahead of print.
Impact of Seasonal Coronavirus Antibodies on SARS-CoV-2 Vaccine Responses in Solid Organ Transplant Recipients
Andrew H Karaba[SUP] 1 [/SUP], Weiqiang Zhou[SUP] 2 [/SUP], Shuai Li[SUP] 2 [/SUP], Tihitina Y Aytenfisu[SUP] 1 [/SUP], Trevor S Johnston[SUP] 1 [/SUP], Olivia Akinde[SUP] 3 [/SUP], Yolanda Eby[SUP] 3 [/SUP], Aura T Abedon[SUP] 4 [/SUP], Jennifer L Alejo[SUP] 4 [/SUP], Caroline X Qin[SUP] 4 [/SUP], Elizabeth A Thompson[SUP] 1 [/SUP], Jacqueline M Garonzik-Wang[SUP] 5 [/SUP], Joel N Blankson[SUP] 1 [/SUP], Andrea L Cox[SUP] 1 6 7 [/SUP], Justin R Bailey[SUP] 1 [/SUP], Sabra L Klein[SUP] 6 [/SUP], Andrew Pekosz[SUP] 6 [/SUP], Dorry L Segev[SUP] 4 8 [/SUP], Aaron A R Tobian[SUP] 3 [/SUP], William A Werbel[SUP] 1 [/SUP]
Affiliations
Abstract
Antibody responses to SARS-CoV-2 vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of pre-existing antibodies to seasonal coronaviruses are associated with decreased antibody response to SARS-CoV-2 vaccination in SOTRs, supporting that antigenic imprinting modulates vaccine responses in this immunosuppressed population.
Keywords: COVID-19; Immunocompromised Hosts; SARS-CoV-2; Vaccines.
. 2022 Aug 12;ciac652.
doi: 10.1093/cid/ciac652. Online ahead of print.
Impact of Seasonal Coronavirus Antibodies on SARS-CoV-2 Vaccine Responses in Solid Organ Transplant Recipients
Andrew H Karaba[SUP] 1 [/SUP], Weiqiang Zhou[SUP] 2 [/SUP], Shuai Li[SUP] 2 [/SUP], Tihitina Y Aytenfisu[SUP] 1 [/SUP], Trevor S Johnston[SUP] 1 [/SUP], Olivia Akinde[SUP] 3 [/SUP], Yolanda Eby[SUP] 3 [/SUP], Aura T Abedon[SUP] 4 [/SUP], Jennifer L Alejo[SUP] 4 [/SUP], Caroline X Qin[SUP] 4 [/SUP], Elizabeth A Thompson[SUP] 1 [/SUP], Jacqueline M Garonzik-Wang[SUP] 5 [/SUP], Joel N Blankson[SUP] 1 [/SUP], Andrea L Cox[SUP] 1 6 7 [/SUP], Justin R Bailey[SUP] 1 [/SUP], Sabra L Klein[SUP] 6 [/SUP], Andrew Pekosz[SUP] 6 [/SUP], Dorry L Segev[SUP] 4 8 [/SUP], Aaron A R Tobian[SUP] 3 [/SUP], William A Werbel[SUP] 1 [/SUP]
Affiliations
- PMID: 35959783
- DOI: 10.1093/cid/ciac652
Abstract
Antibody responses to SARS-CoV-2 vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of pre-existing antibodies to seasonal coronaviruses are associated with decreased antibody response to SARS-CoV-2 vaccination in SOTRs, supporting that antigenic imprinting modulates vaccine responses in this immunosuppressed population.
Keywords: COVID-19; Immunocompromised Hosts; SARS-CoV-2; Vaccines.