tetano
Editor, Senior Moderator
Clin Infect Dis
. 2022 Jan 17;ciac028.
doi: 10.1093/cid/ciac028. Online ahead of print.
Clinical characteristics and outcomes of COVID-19 in pregnant women: a propensity score matched analysis of the data from the COVID-19 Registry Japan
Kensuke Shoji[SUP] 1 [/SUP], Shinya Tsuzuki[SUP] 2 [/SUP], Takayuki Akiyama[SUP] 2 [/SUP], Nobuaki Matsunaga[SUP] 2 [/SUP], Yusuke Asai[SUP] 2 [/SUP], Setsuko Suzuki[SUP] 3 [/SUP], Noriko Iwamoto[SUP] 3 [/SUP], Takanori Funaki[SUP] 1 [/SUP], Masaki Yamada[SUP] 1 4 [/SUP], Nobuaki Ozawa[SUP] 5 [/SUP], Koushi Yamaguchi[SUP] 5 [/SUP], Isao Miyairi[SUP] 1 6 [/SUP], Norio Ohmagari[SUP] 2 3 [/SUP]
Affiliations
Abstract
Background: Several studies have investigated whether pregnancy is a risk factor for developing severe COVID-19; however, the results remain controversial. In addition, the information regarding risk factors for developing severe COVID-19 in pregnant women is limited.
Methods: A retrospective cohort study analyzing the data from the nationwide COVID-19 registry in Japan was conducted. Propensity score matched analysis was performed to compare COVID-19 severity between pregnant and nonpregnant women. Multivariate analysis was also conducted to evaluate risk factors for developing moderate-to-severe COVID-19 in pregnant women.
Results: During the study period, 254 pregnant and 3752 nonpregnant women of reproductive age were identified. After propensity score matching, 187 pregnant women and 935 nonpregnant women were selected. A composite outcome of moderate-to-severe COVID-19 was more frequently observed in pregnant women than that of nonpregnant women (n=18, 9.6% vs. n=46, 4.9%; P=0.0155). In multivariate analysis, the presence of underlying diseases and being in the second-to-third trimester of pregnancy were recognized as risk factors for moderate-to-severe COVID-19 in pregnant women (odds ratio [95% confidence interval]: 5.295 [1.21-23.069] and 3.871 [1.201-12.477], respectively).
Conclusions: Pregnancy could be a risk factor for moderate-to-severe COVID-19 for women in Japan. In addition to the presence of comorbidities, advanced pregnancy stages may contribute to greater risks for developing moderate-to-severe COVID-19 in pregnant women.
Keywords: coronavirus disease 2019; pregnant women; propensity score matched analysis; severe acute respiratory syndrome coronavirus 2.
. 2022 Jan 17;ciac028.
doi: 10.1093/cid/ciac028. Online ahead of print.
Clinical characteristics and outcomes of COVID-19 in pregnant women: a propensity score matched analysis of the data from the COVID-19 Registry Japan
Kensuke Shoji[SUP] 1 [/SUP], Shinya Tsuzuki[SUP] 2 [/SUP], Takayuki Akiyama[SUP] 2 [/SUP], Nobuaki Matsunaga[SUP] 2 [/SUP], Yusuke Asai[SUP] 2 [/SUP], Setsuko Suzuki[SUP] 3 [/SUP], Noriko Iwamoto[SUP] 3 [/SUP], Takanori Funaki[SUP] 1 [/SUP], Masaki Yamada[SUP] 1 4 [/SUP], Nobuaki Ozawa[SUP] 5 [/SUP], Koushi Yamaguchi[SUP] 5 [/SUP], Isao Miyairi[SUP] 1 6 [/SUP], Norio Ohmagari[SUP] 2 3 [/SUP]
Affiliations
- PMID: 35037051
- DOI: 10.1093/cid/ciac028
Abstract
Background: Several studies have investigated whether pregnancy is a risk factor for developing severe COVID-19; however, the results remain controversial. In addition, the information regarding risk factors for developing severe COVID-19 in pregnant women is limited.
Methods: A retrospective cohort study analyzing the data from the nationwide COVID-19 registry in Japan was conducted. Propensity score matched analysis was performed to compare COVID-19 severity between pregnant and nonpregnant women. Multivariate analysis was also conducted to evaluate risk factors for developing moderate-to-severe COVID-19 in pregnant women.
Results: During the study period, 254 pregnant and 3752 nonpregnant women of reproductive age were identified. After propensity score matching, 187 pregnant women and 935 nonpregnant women were selected. A composite outcome of moderate-to-severe COVID-19 was more frequently observed in pregnant women than that of nonpregnant women (n=18, 9.6% vs. n=46, 4.9%; P=0.0155). In multivariate analysis, the presence of underlying diseases and being in the second-to-third trimester of pregnancy were recognized as risk factors for moderate-to-severe COVID-19 in pregnant women (odds ratio [95% confidence interval]: 5.295 [1.21-23.069] and 3.871 [1.201-12.477], respectively).
Conclusions: Pregnancy could be a risk factor for moderate-to-severe COVID-19 for women in Japan. In addition to the presence of comorbidities, advanced pregnancy stages may contribute to greater risks for developing moderate-to-severe COVID-19 in pregnant women.
Keywords: coronavirus disease 2019; pregnant women; propensity score matched analysis; severe acute respiratory syndrome coronavirus 2.