tetano
Editor, Senior Moderator
Clin Infect Dis
. 2022 Jun 10;ciac469.
doi: 10.1093/cid/ciac469. Online ahead of print.
Association of Trends in SARS-CoV-2 Seroprevalence and State-Issued Nonpharmaceutical Interventions- United States, August 1, 2020 - March 30, 2021
Maureen J Miller[SUP] 1 [/SUP], Austin Himschoot[SUP] 2 [/SUP], Natalie Fitch[SUP] 2 [/SUP], Sucheta Jawalkar[SUP] 2 [/SUP], Dane Freeman[SUP] 2 [/SUP], Charity Hilton[SUP] 2 [/SUP], Kevin Berney[SUP] 3 [/SUP], Gery P Guy[SUP] 1 [/SUP], Tina J Benoit[SUP] 1 [/SUP], Kristie E N Clarke[SUP] 1 [/SUP], Michael P Busch[SUP] 4 [/SUP], Jean D Opsomer[SUP] 5 [/SUP], Susan L Stramer[SUP] 6 [/SUP], Aron J Hall[SUP] 1 [/SUP], Adi V Gundlapalli[SUP] 1 [/SUP], Adam MacNeil[SUP] 1 [/SUP], Russell McCord[SUP] 1 [/SUP], Gregory Sunshine[SUP] 1 [/SUP], Mara Howard-Williams[SUP] 1 [/SUP], Christopher Dunphy[SUP] 1 [/SUP], Jefferson M Jones[SUP] 1 [/SUP]
Affiliations
Abstract
Objectives: To assess if state-issued nonpharmaceutical interventions (NPIs) are associated with reduced rates of SARS-CoV-2 infection as measured through anti-nucleocapsid (anti-N) seroprevalence, a proxy for cumulative prior infection that distinguishes seropositivity from vaccination).
Methods: Monthly anti-N seroprevalence during August 1, 2020 - March 30, 2021 was estimated using a nationwide blood donor serosurvey. Using multivariable logistic regression models, we measured the association of seropositivity and state-issued, county-specific NPIs for mask mandates, gathering bans, and bar closures.
Results: Compared with individuals living in a county with all three NPIs in place, the odds of having anti-N antibodies were 2.2 (95% CI: 2.0-2.3) times higher for people living in a county that did not have any of the three NPIs, 1.6 (95% CI: 1.5-1.7) times higher for people living in a county that only had a mask mandate and gathering ban policy, and 1.4 (95% CI: 1.3-1.5) times higher for people living in a county that had only a mask mandate.
Conclusions: Consistent with studies assessing NPIs relative to COVID-19 incidence and mortality, the presence of NPIs were associated with lower SARS-CoV-2 seroprevalence indicating lower rates of cumulative infections. Multiple NPIs are likely more effective than single NPIs.
Keywords: COVID-19; SARS-CoV-2; nonpharmaceutical interventions; novel coronavirus; seroprevalence.
. 2022 Jun 10;ciac469.
doi: 10.1093/cid/ciac469. Online ahead of print.
Association of Trends in SARS-CoV-2 Seroprevalence and State-Issued Nonpharmaceutical Interventions- United States, August 1, 2020 - March 30, 2021
Maureen J Miller[SUP] 1 [/SUP], Austin Himschoot[SUP] 2 [/SUP], Natalie Fitch[SUP] 2 [/SUP], Sucheta Jawalkar[SUP] 2 [/SUP], Dane Freeman[SUP] 2 [/SUP], Charity Hilton[SUP] 2 [/SUP], Kevin Berney[SUP] 3 [/SUP], Gery P Guy[SUP] 1 [/SUP], Tina J Benoit[SUP] 1 [/SUP], Kristie E N Clarke[SUP] 1 [/SUP], Michael P Busch[SUP] 4 [/SUP], Jean D Opsomer[SUP] 5 [/SUP], Susan L Stramer[SUP] 6 [/SUP], Aron J Hall[SUP] 1 [/SUP], Adi V Gundlapalli[SUP] 1 [/SUP], Adam MacNeil[SUP] 1 [/SUP], Russell McCord[SUP] 1 [/SUP], Gregory Sunshine[SUP] 1 [/SUP], Mara Howard-Williams[SUP] 1 [/SUP], Christopher Dunphy[SUP] 1 [/SUP], Jefferson M Jones[SUP] 1 [/SUP]
Affiliations
- PMID: 35684974
- DOI: 10.1093/cid/ciac469
Abstract
Objectives: To assess if state-issued nonpharmaceutical interventions (NPIs) are associated with reduced rates of SARS-CoV-2 infection as measured through anti-nucleocapsid (anti-N) seroprevalence, a proxy for cumulative prior infection that distinguishes seropositivity from vaccination).
Methods: Monthly anti-N seroprevalence during August 1, 2020 - March 30, 2021 was estimated using a nationwide blood donor serosurvey. Using multivariable logistic regression models, we measured the association of seropositivity and state-issued, county-specific NPIs for mask mandates, gathering bans, and bar closures.
Results: Compared with individuals living in a county with all three NPIs in place, the odds of having anti-N antibodies were 2.2 (95% CI: 2.0-2.3) times higher for people living in a county that did not have any of the three NPIs, 1.6 (95% CI: 1.5-1.7) times higher for people living in a county that only had a mask mandate and gathering ban policy, and 1.4 (95% CI: 1.3-1.5) times higher for people living in a county that had only a mask mandate.
Conclusions: Consistent with studies assessing NPIs relative to COVID-19 incidence and mortality, the presence of NPIs were associated with lower SARS-CoV-2 seroprevalence indicating lower rates of cumulative infections. Multiple NPIs are likely more effective than single NPIs.
Keywords: COVID-19; SARS-CoV-2; nonpharmaceutical interventions; novel coronavirus; seroprevalence.