Giuseppe
Emeritus
[Source: Clinical Infectious Diseases, full page: (LINK). Abstract, edited.]
Antibacterial Bio-Agents Based on Principles of Bacteriophage Biology - An Overview
Bettina M. Knoll and Eleftherios Mylonakis
Author Affiliations: Department of Medicine, Infectious Diseases Division, Rhode Island Hospital, Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI 02903, USA
Corresponding Author: Bettina M. Knoll MD, PhD, Rhode Island Hospital, Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, Rhode Island 02903, USA, Tel.:+1 401 444 3869; fax:+1 401 444 8145, Email: bknoll@lifespan.org
<CITE><ABBR>Clin Infect Dis.</ABBR> (2013) doi: 10.1093/cid/cit771 / </CITE>First published online: November 23, 2013
Abstract
Bacteriophages were discovered almost a century ago. With the advent of antibiotics their use for treatment of infections fell out of favor in Western medicine. In light of the rise of antibiotic resistance, phages and their products (lysins) are re-discovered as antibacterial bio-agents. This overview summarizes principles of phage biology and their translation for therapeutic and preventive applications. Examples are presented to highlight their therapeutic promise for prophylaxis and treatment of bacterial infections including multi-drug resistant organisms in humans and animals, and their use as decontaminants of food supplies and environments. Besides research on the in vivo behavior of phages and lysins, dialogues between researchers and regulatory agencies are necessary to publish guidelines for bacteriophage manufacturing and formulation for human use. Only well-designed double-blind randomized controlled trials will determine if phages and lysins are safe and effective adjuncts or alternatives to antibiotic therapy for infections with multi drug-resistant organisms.
Received July 12, 2013. Accepted October 9, 2013.
? The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
For Permissions, please e-mail: journals.permissions@oup.com.
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Antibacterial Bio-Agents Based on Principles of Bacteriophage Biology - An Overview
Bettina M. Knoll and Eleftherios Mylonakis
Author Affiliations: Department of Medicine, Infectious Diseases Division, Rhode Island Hospital, Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI 02903, USA
Corresponding Author: Bettina M. Knoll MD, PhD, Rhode Island Hospital, Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, Rhode Island 02903, USA, Tel.:+1 401 444 3869; fax:+1 401 444 8145, Email: bknoll@lifespan.org
<CITE><ABBR>Clin Infect Dis.</ABBR> (2013) doi: 10.1093/cid/cit771 / </CITE>First published online: November 23, 2013
Abstract
Bacteriophages were discovered almost a century ago. With the advent of antibiotics their use for treatment of infections fell out of favor in Western medicine. In light of the rise of antibiotic resistance, phages and their products (lysins) are re-discovered as antibacterial bio-agents. This overview summarizes principles of phage biology and their translation for therapeutic and preventive applications. Examples are presented to highlight their therapeutic promise for prophylaxis and treatment of bacterial infections including multi-drug resistant organisms in humans and animals, and their use as decontaminants of food supplies and environments. Besides research on the in vivo behavior of phages and lysins, dialogues between researchers and regulatory agencies are necessary to publish guidelines for bacteriophage manufacturing and formulation for human use. Only well-designed double-blind randomized controlled trials will determine if phages and lysins are safe and effective adjuncts or alternatives to antibiotic therapy for infections with multi drug-resistant organisms.
Received July 12, 2013. Accepted October 9, 2013.
? The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
For Permissions, please e-mail: journals.permissions@oup.com.
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