tetano
Editor, Senior Moderator
Clin Infect Dis
. 2022 May 6;ciab1005.
doi: 10.1093/cid/ciab1005. Online ahead of print.
Alpha variant coronavirus outbreak in a nursing home despite high vaccination coverage: molecular, epidemiological and immunological studies
Kathrin Zürcher[SUP] 1 [/SUP], Irene A Abela[SUP] 2 3 [/SUP], Madlen Stange[SUP] 4 5 [/SUP], Carole Dupont[SUP] 1 [/SUP], Catrina Mugglin[SUP] 1 6 [/SUP], Adrian Egli[SUP] 4 5 [/SUP], Alexandra Trkola[SUP] 2 [/SUP], Matthias Egger[SUP] 1 7 8 [/SUP], Lukas Fenner[SUP] 1 6 [/SUP]
Affiliations
Abstract
Background: Vaccination may control the COVID-19 pandemic, including in nursing homes where many high-risk people live. We conducted extensive outbreak investigations.
Methods: We studied an outbreak at a nursing home in Switzerland where vaccination uptake of mRNA vaccines against SARS-CoV-2 was 82% among residents as of Jan 21/2021. After a vaccinated symptomatic HCW was diagnosed with COVID-19 on Feb 22, we did an outbreak investigations in house A (47 residents, 37 HCWs) using SARS-CoV-2-specific PCR in nasopharyngeal swabs. We performed whole-genome sequencing of SARS-CoV-2 and serological analyses.
Results: We identified 17 individuals with positive PCR tests; ten residents (five vaccinated) and seven HCWs (three vaccinated). Median age among residents was 86 years (interquartile range [IQR] 70-90) and 49 years (IQR 29-59) among HCWs. Among the five vaccinated residents, 60% had mild disease and had 40% no symptoms, whereas all five unvaccinated residents had mild to severe disease and two died. The vaccine effectiveness for the prevention of infection among the residents was 73.0% (95% Cl 24.7-90.1). The 12 available genomes were all alpha variants. Neutralizing titers were significantly higher in vaccinated individuals upon re-exposure (>1 week after diagnosis) than in vaccinated, unexposed HCWs (p=0.012). Transmission networks indicated four likely or possible transmissions from vaccinated to other individuals, and 12 transmission events from unvaccinated individuals.
Conclusions: COVID-19 outbreaks can occur in nursing homes, including transmission from vaccinated persons to others. Outbreaks might occur silently, underlining the need for continued testing and basic infection control measures in these high-risk settings.
Keywords: B.1.1.7; COVID-19; UK variant; nursing home; outbreak; vaccine.
. 2022 May 6;ciab1005.
doi: 10.1093/cid/ciab1005. Online ahead of print.
Alpha variant coronavirus outbreak in a nursing home despite high vaccination coverage: molecular, epidemiological and immunological studies
Kathrin Zürcher[SUP] 1 [/SUP], Irene A Abela[SUP] 2 3 [/SUP], Madlen Stange[SUP] 4 5 [/SUP], Carole Dupont[SUP] 1 [/SUP], Catrina Mugglin[SUP] 1 6 [/SUP], Adrian Egli[SUP] 4 5 [/SUP], Alexandra Trkola[SUP] 2 [/SUP], Matthias Egger[SUP] 1 7 8 [/SUP], Lukas Fenner[SUP] 1 6 [/SUP]
Affiliations
- PMID: 35522980
- DOI: 10.1093/cid/ciab1005
Abstract
Background: Vaccination may control the COVID-19 pandemic, including in nursing homes where many high-risk people live. We conducted extensive outbreak investigations.
Methods: We studied an outbreak at a nursing home in Switzerland where vaccination uptake of mRNA vaccines against SARS-CoV-2 was 82% among residents as of Jan 21/2021. After a vaccinated symptomatic HCW was diagnosed with COVID-19 on Feb 22, we did an outbreak investigations in house A (47 residents, 37 HCWs) using SARS-CoV-2-specific PCR in nasopharyngeal swabs. We performed whole-genome sequencing of SARS-CoV-2 and serological analyses.
Results: We identified 17 individuals with positive PCR tests; ten residents (five vaccinated) and seven HCWs (three vaccinated). Median age among residents was 86 years (interquartile range [IQR] 70-90) and 49 years (IQR 29-59) among HCWs. Among the five vaccinated residents, 60% had mild disease and had 40% no symptoms, whereas all five unvaccinated residents had mild to severe disease and two died. The vaccine effectiveness for the prevention of infection among the residents was 73.0% (95% Cl 24.7-90.1). The 12 available genomes were all alpha variants. Neutralizing titers were significantly higher in vaccinated individuals upon re-exposure (>1 week after diagnosis) than in vaccinated, unexposed HCWs (p=0.012). Transmission networks indicated four likely or possible transmissions from vaccinated to other individuals, and 12 transmission events from unvaccinated individuals.
Conclusions: COVID-19 outbreaks can occur in nursing homes, including transmission from vaccinated persons to others. Outbreaks might occur silently, underlining the need for continued testing and basic infection control measures in these high-risk settings.
Keywords: B.1.1.7; COVID-19; UK variant; nursing home; outbreak; vaccine.