tetano
Editor, Senior Moderator
Clin Immunol
. 2020 Jul 28;108548.
doi: 10.1016/j.clim.2020.108548. Online ahead of print.
The cellular immunophenotype expression of influenza A virus and influenza B virus infection in children
Ching-Fen Shen[SUP] 1 [/SUP], Tzong-Shiann Ho[SUP] 2 [/SUP], Shih-Min Wang[SUP] 3 [/SUP], Yu-Ting Liao[SUP] 2 [/SUP], Yu-Shiang Hu[SUP] 2 [/SUP], Huey-Pin Tsai[SUP] 4 [/SUP], Shun-Hua Chen[SUP] 5 [/SUP]
Affiliations
Abstract
Background: The innate immune response is the primary defense against influenza virus infection.
Methods: This is a prospective study carried out in children <18 years of age who were diagnosed with influenza A or influenza B infection. Demographic and clinical data, laboratory findings and cell immunophenotypes on first presentation were compared.
Results: With respect to immunophenotype, influenza A infection resulted in a higher fraction of CD14[SUP]+[/SUP] cells compared to children infected with influenza B. By contrast, influenza B infection resulted in a comparatively higher percentage of various lymphocyte subsets including double-negative CD4[SUP]-[/SUP]CD8[SUP]-[/SUP] and CD4[SUP]+[/SUP]IL-17A[SUP]+[/SUP] cells. Influenza A infection was associated with comparatively higher percentages of CD4[SUP]+[/SUP]CD25[SUP]high[/SUP] and CD8[SUP]+[/SUP]CD25[SUP]high[/SUP] cells. By contrast, influenza B infection resulted in comparatively higher percentages of CD4[SUP]+[/SUP]CD25[SUP]low[/SUP], CD8[SUP]+[/SUP]CD25[SUP]low[/SUP] and CD4[SUP]+[/SUP]CD25[SUP]low[/SUP]Foxp3[SUP]+[/SUP] cells.
Conclusions: An improved understanding of the fraction of regulatory T cells with influenza virus infections may provide further understandings on immune responses.
Keywords: Antivirals; CD25; Immunophenotype; Influenza virus; Treg.
. 2020 Jul 28;108548.
doi: 10.1016/j.clim.2020.108548. Online ahead of print.
The cellular immunophenotype expression of influenza A virus and influenza B virus infection in children
Ching-Fen Shen[SUP] 1 [/SUP], Tzong-Shiann Ho[SUP] 2 [/SUP], Shih-Min Wang[SUP] 3 [/SUP], Yu-Ting Liao[SUP] 2 [/SUP], Yu-Shiang Hu[SUP] 2 [/SUP], Huey-Pin Tsai[SUP] 4 [/SUP], Shun-Hua Chen[SUP] 5 [/SUP]
Affiliations
- PMID: 32735869
- DOI: 10.1016/j.clim.2020.108548
Abstract
Background: The innate immune response is the primary defense against influenza virus infection.
Methods: This is a prospective study carried out in children <18 years of age who were diagnosed with influenza A or influenza B infection. Demographic and clinical data, laboratory findings and cell immunophenotypes on first presentation were compared.
Results: With respect to immunophenotype, influenza A infection resulted in a higher fraction of CD14[SUP]+[/SUP] cells compared to children infected with influenza B. By contrast, influenza B infection resulted in a comparatively higher percentage of various lymphocyte subsets including double-negative CD4[SUP]-[/SUP]CD8[SUP]-[/SUP] and CD4[SUP]+[/SUP]IL-17A[SUP]+[/SUP] cells. Influenza A infection was associated with comparatively higher percentages of CD4[SUP]+[/SUP]CD25[SUP]high[/SUP] and CD8[SUP]+[/SUP]CD25[SUP]high[/SUP] cells. By contrast, influenza B infection resulted in comparatively higher percentages of CD4[SUP]+[/SUP]CD25[SUP]low[/SUP], CD8[SUP]+[/SUP]CD25[SUP]low[/SUP] and CD4[SUP]+[/SUP]CD25[SUP]low[/SUP]Foxp3[SUP]+[/SUP] cells.
Conclusions: An improved understanding of the fraction of regulatory T cells with influenza virus infections may provide further understandings on immune responses.
Keywords: Antivirals; CD25; Immunophenotype; Influenza virus; Treg.