tetano
Editor, Senior Moderator
Clin Immunol
. 2020 Oct 14;108611.
doi: 10.1016/j.clim.2020.108611. Online ahead of print.
Proinflammatory cytokines are associated with prolonged viral RNA shedding in COVID-19 patients
Chun Gao[SUP] 1 [/SUP], Li Zhu[SUP] 1 [/SUP], Cheng Cheng Jin[SUP] 1 [/SUP], Yi Xin Tong[SUP] 1 [/SUP], Ai Tang Xiao[SUP] 1 [/SUP], Sheng Zhang[SUP] 2 [/SUP]
Affiliations
Abstract
Since December 2019, Coronavirus Disease 2019 (COVID-19) has emerged as a global pandemic. We aimed to investigate the clinical characteristics and analyzed the risk factors for prolonged viral RNA shedding. We retrospectively collected data from 112 hospitalized COVID-19 patients in a single center in Wuhan, China. Factors associated with prolonged viral RNA shedding (≥28 days) were investigated. Forty-nine (43.8%) patients had prolonged viral RNA shedding. Patients with prolonged viral shedding were older and had a higher rate of hypertension. Proinflammatory cytokines, including interleukin-2R (IL-2R) and tumor necrosis factor-α (TNF-α), were significantly elevated in patients with prolonged viral shedding. Multivariate analysis revealed that hypertension, older age, lymphopenia and elevated serum IL-2R were independent risk factors for prolonged viral shedding. This comprehensive investigation revealed the distinct characteristics between patients with or without prolonged viral RNA shedding. Hypertension, older age, lymphopenia and high levels of proinflammatory cytokines may be correlated with prolonged viral shedding.
Keywords: Coronavirus disease 2019; Lymphopenia; Proinflammatory cytokines; Prolonged viral RNA shedding; SARS-CoV-2.
. 2020 Oct 14;108611.
doi: 10.1016/j.clim.2020.108611. Online ahead of print.
Proinflammatory cytokines are associated with prolonged viral RNA shedding in COVID-19 patients
Chun Gao[SUP] 1 [/SUP], Li Zhu[SUP] 1 [/SUP], Cheng Cheng Jin[SUP] 1 [/SUP], Yi Xin Tong[SUP] 1 [/SUP], Ai Tang Xiao[SUP] 1 [/SUP], Sheng Zhang[SUP] 2 [/SUP]
Affiliations
- PMID: 33068796
- PMCID: PMC7554496
- DOI: 10.1016/j.clim.2020.108611
Abstract
Since December 2019, Coronavirus Disease 2019 (COVID-19) has emerged as a global pandemic. We aimed to investigate the clinical characteristics and analyzed the risk factors for prolonged viral RNA shedding. We retrospectively collected data from 112 hospitalized COVID-19 patients in a single center in Wuhan, China. Factors associated with prolonged viral RNA shedding (≥28 days) were investigated. Forty-nine (43.8%) patients had prolonged viral RNA shedding. Patients with prolonged viral shedding were older and had a higher rate of hypertension. Proinflammatory cytokines, including interleukin-2R (IL-2R) and tumor necrosis factor-α (TNF-α), were significantly elevated in patients with prolonged viral shedding. Multivariate analysis revealed that hypertension, older age, lymphopenia and elevated serum IL-2R were independent risk factors for prolonged viral shedding. This comprehensive investigation revealed the distinct characteristics between patients with or without prolonged viral RNA shedding. Hypertension, older age, lymphopenia and high levels of proinflammatory cytokines may be correlated with prolonged viral shedding.
Keywords: Coronavirus disease 2019; Lymphopenia; Proinflammatory cytokines; Prolonged viral RNA shedding; SARS-CoV-2.