Clin Immunol . Decrease in CD8 + CD45 + CCR7 + CD62L + T cells in individuals vaccinated with Sinovac-CoronaVac following COVID-19 infection

[tetano]

Clin Immunol


. 2022 Aug 6;109092.
doi: 10.1016/j.clim.2022.109092. Online ahead of print.
Decrease in CD8 [SUP]+[/SUP] CD45 [SUP]+[/SUP] CCR7 [SUP]+[/SUP] CD62L [SUP]+[/SUP] T cells in individuals vaccinated with Sinovac-CoronaVac following COVID-19 infection


Dâmaris C S C Fonseca[SUP] 1 [/SUP], Mirtes C B Rocha[SUP] 2 [/SUP], Lucca A Pereira[SUP] 1 [/SUP], Leticia P Botega[SUP] 1 [/SUP], Susanne C P F Cutrim[SUP] 1 [/SUP], Fabiano V Silva[SUP] 3 [/SUP], Flávio D Batista[SUP] 4 [/SUP], Adriana S Rêgo[SUP] 4 [/SUP], Ângela Falcai[SUP] 4 [/SUP], Lídio G Lima-Neto[SUP] 5 [/SUP], Ana Paula S A Santos[SUP] 4 [/SUP], Rafael C Carvalho[SUP] 4 [/SUP], Eduardo M Sousa[SUP] 6 [/SUP]



Affiliations

• PMID: 35944882
• DOI: 10.1016/j.clim.2022.109092

Abstract

Vaccines induce antibodies, but T cell responses are also important for protection against Coronavirus disease 2019. Here, we analyzed the frequency of memory T cells in infected and/or vaccinated individuals and observed a decrease in central memory T cells in individuals who were vaccinated following COVID-19 infection.

Keywords: COVID-19; Immune memory; T cells; Vaccination.