tetano
Editor, Senior Moderator
Clin Exp Vaccine Res
. 2026 Jul;15(3):202-208.
doi: 10.7774/cevr.2026.15.e19. Epub 2026 Jul 9.
The impact of influenza vaccination on the clinical severity of influenza among children aged 6 months to 6 years living in the community: a prospective cohort study
Xiaoman Cai[SUP] 1 [/SUP], Ailing Zhang[SUP] 2 [/SUP], Shiyou Luo[SUP] 1 [/SUP], Xiubin Ma[SUP] 1 [/SUP], Bin Wang[SUP] 1 [/SUP], Xueying Meng[SUP] 1 [/SUP], Yaoting Su[SUP] 3 [/SUP]
Affiliations
Purpose: Evidence on whether influenza vaccination reduces disease severity in children with breakthrough infections in community settings is limited.
Materials and methods: This prospective study enrolled 388 children (aged 6 months-6 years) diagnosed with influenza at a community health center in Shenzhen from May 2024 to October 2025. Participants were grouped by vaccination status within the prior year: vaccinated (n=196) and unvaccinated (n=192). Clinical characteristics, healthcare utilization, and outcomes were compared.
Results: Vaccinated children showed significantly lower peak body temperature (38.81°C±0.58°C vs. 39.03°C±0.64°C), shorter fever duration (2.01±1.21 days vs. 2.45±1.55 days), and fewer symptoms like myalgia and gastrointestinal issues (all p<0.01). They also had fewer outpatient visits, lower outpatient costs, and markedly reduced rates of hospitalization (4.1% vs. 21.9%) and antibiotic use (5.6% vs. 15.1%) (all p<0.05).
Conclusion: Influenza vaccination could mitigate symptoms, reduce hospitalization and antibiotic use, and lessen the healthcare burden from breakthrough infections.
Keywords: Children; Community-acquired influenza; Disease severity; Influenza vaccine; Prospective cohort.
. 2026 Jul;15(3):202-208.
doi: 10.7774/cevr.2026.15.e19. Epub 2026 Jul 9.
The impact of influenza vaccination on the clinical severity of influenza among children aged 6 months to 6 years living in the community: a prospective cohort study
Xiaoman Cai[SUP] 1 [/SUP], Ailing Zhang[SUP] 2 [/SUP], Shiyou Luo[SUP] 1 [/SUP], Xiubin Ma[SUP] 1 [/SUP], Bin Wang[SUP] 1 [/SUP], Xueying Meng[SUP] 1 [/SUP], Yaoting Su[SUP] 3 [/SUP]
Affiliations
- PMID: 42565186
- PMCID: PMC13447002
- DOI: 10.7774/cevr.2026.15.e19
Purpose: Evidence on whether influenza vaccination reduces disease severity in children with breakthrough infections in community settings is limited.
Materials and methods: This prospective study enrolled 388 children (aged 6 months-6 years) diagnosed with influenza at a community health center in Shenzhen from May 2024 to October 2025. Participants were grouped by vaccination status within the prior year: vaccinated (n=196) and unvaccinated (n=192). Clinical characteristics, healthcare utilization, and outcomes were compared.
Results: Vaccinated children showed significantly lower peak body temperature (38.81°C±0.58°C vs. 39.03°C±0.64°C), shorter fever duration (2.01±1.21 days vs. 2.45±1.55 days), and fewer symptoms like myalgia and gastrointestinal issues (all p<0.01). They also had fewer outpatient visits, lower outpatient costs, and markedly reduced rates of hospitalization (4.1% vs. 21.9%) and antibiotic use (5.6% vs. 15.1%) (all p<0.05).
Conclusion: Influenza vaccination could mitigate symptoms, reduce hospitalization and antibiotic use, and lessen the healthcare burden from breakthrough infections.
Keywords: Children; Community-acquired influenza; Disease severity; Influenza vaccine; Prospective cohort.