tetano
Editor, Senior Moderator
Clin Exp Reprod Med
. 2022 Mar;49(1):2-8.
doi: 10.5653/cerm.2022.05225. Epub 2022 Feb 28.
Effects and safety of COVID-19 vaccination on assisted reproductive technology and pregnancy: A comprehensive review and joint statements of the KSRM, the KSRI, and the KOSAR
Ae Ra Han[SUP] 1 [/SUP], Dayong Lee[SUP] 2 [/SUP], Seul Ki Kim[SUP] 3 4 [/SUP], Chang Woo Choo[SUP] 5 [/SUP], Joon Cheol Park[SUP] 6 [/SUP], Jung Ryeol Lee[SUP] 3 4 [/SUP], Won Jun Choi[SUP] 7 [/SUP], Jin Hyun Jun[SUP] 8 9 10 [/SUP], Jeong Ho Rhee[SUP] 6 [/SUP], Seok Hyun Kim[SUP] 3 [/SUP], Korean Society for Reproductive Medicine (KSRM); Korean Society for Reproductive Immunology (KSRI); Korean Society for Assisted Reproduction (KOSAR)
Affiliations
Abstract
Humanity is in the midst of the coronavirus disease 2019 (COVID-19) pandemic, and vaccines-including mRNA vaccines-have been developed at an unprecedented speed. It is necessary to develop guidelines for vaccination for people undergoing treatment with assisted reproductive technology (ART) and for pregnancy-related situations based on the extant laboratory and clinical data. COVID-19 vaccines do not appear to adversely affect gametes, embryos, or implantation; therefore, active vaccination is recommended for women or men who are preparing for ART. The use of intravenous immunoglobulin G (IVIG) for the treatment of immune-related infertility is unlikely to impact the effectiveness of the vaccines, so COVID-19 vaccines can be administered around ART cycles in which IVIG is scheduled. Pregnant women have been proven to be at risk of severe maternal and neonatal complications from COVID-19. It does not appear that COVID-19 vaccines harm pregnant women or fetuses; instead, they have been observed to deliver antibodies against severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) to the fetus. Accordingly, it is recommended that pregnant women receive COVID-19 vaccination. There is no rationale for adverse effects, or clinical cases of adverse reactions, in mothers or neonates after COVID-19 vaccination in lactating women. Instead, antibodies to SARS-CoV-2 can be delivered through breast milk. Therefore, breastfeeding mothers should consider vaccination. In summary, active administration of COVID-19 vaccines will help ensure the safe implementation of ART, pregnancy, and breastfeeding.
Keywords: Assisted reproductive technology; COVID-19; Lactation; Pregnancy; Vaccination.
. 2022 Mar;49(1):2-8.
doi: 10.5653/cerm.2022.05225. Epub 2022 Feb 28.
Effects and safety of COVID-19 vaccination on assisted reproductive technology and pregnancy: A comprehensive review and joint statements of the KSRM, the KSRI, and the KOSAR
Ae Ra Han[SUP] 1 [/SUP], Dayong Lee[SUP] 2 [/SUP], Seul Ki Kim[SUP] 3 4 [/SUP], Chang Woo Choo[SUP] 5 [/SUP], Joon Cheol Park[SUP] 6 [/SUP], Jung Ryeol Lee[SUP] 3 4 [/SUP], Won Jun Choi[SUP] 7 [/SUP], Jin Hyun Jun[SUP] 8 9 10 [/SUP], Jeong Ho Rhee[SUP] 6 [/SUP], Seok Hyun Kim[SUP] 3 [/SUP], Korean Society for Reproductive Medicine (KSRM); Korean Society for Reproductive Immunology (KSRI); Korean Society for Assisted Reproduction (KOSAR)
Affiliations
- PMID: 35255653
- DOI: 10.5653/cerm.2022.05225
Abstract
Humanity is in the midst of the coronavirus disease 2019 (COVID-19) pandemic, and vaccines-including mRNA vaccines-have been developed at an unprecedented speed. It is necessary to develop guidelines for vaccination for people undergoing treatment with assisted reproductive technology (ART) and for pregnancy-related situations based on the extant laboratory and clinical data. COVID-19 vaccines do not appear to adversely affect gametes, embryos, or implantation; therefore, active vaccination is recommended for women or men who are preparing for ART. The use of intravenous immunoglobulin G (IVIG) for the treatment of immune-related infertility is unlikely to impact the effectiveness of the vaccines, so COVID-19 vaccines can be administered around ART cycles in which IVIG is scheduled. Pregnant women have been proven to be at risk of severe maternal and neonatal complications from COVID-19. It does not appear that COVID-19 vaccines harm pregnant women or fetuses; instead, they have been observed to deliver antibodies against severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) to the fetus. Accordingly, it is recommended that pregnant women receive COVID-19 vaccination. There is no rationale for adverse effects, or clinical cases of adverse reactions, in mothers or neonates after COVID-19 vaccination in lactating women. Instead, antibodies to SARS-CoV-2 can be delivered through breast milk. Therefore, breastfeeding mothers should consider vaccination. In summary, active administration of COVID-19 vaccines will help ensure the safe implementation of ART, pregnancy, and breastfeeding.
Keywords: Assisted reproductive technology; COVID-19; Lactation; Pregnancy; Vaccination.