tetano
Editor, Senior Moderator
Clin Exp Med
. 2023 Jul 21.
doi: 10.1007/s10238-023-01139-5. Online ahead of print. Interactions and clinical implications of serological and respiratory variables 3 months after acute COVID-19
Ophir Freund[SUP] 1 [/SUP], Anna Breslavsky[SUP] 2 [/SUP], Sabrina Fried[SUP] 3 [/SUP], Rotem Givoli-Vilensky[SUP] 4 [/SUP], Shira Cohen-Rubin[SUP] 4 [/SUP], Nadav Zacks[SUP] 4 [/SUP], Eyal Kleinhendler[SUP] 3 [/SUP], Avraham Unterman[SUP] 3 [/SUP], Shir Frydman[SUP] 3 [/SUP], Ori Wand[SUP] 2 [/SUP], Natalya Bilenko[SUP] 4 5 [/SUP], Amir Bar-Shai[SUP] 3 [/SUP]
Affiliations
Medical follow-up of symptomatic patients after acute Coronavirus Disease 2019 (COVID-19) results in major burdens on patients and healthcare systems. The value of serological markers as part of this follow-up remains undetermined. We aimed to evaluate the clinical implications of serological markers for follow-up of acute COVID-19. For this purpose, we conducted an observational cohort study of patients 3 months after acute COVID-19. Participants visited a respiratory-clinic between October 2020 and March 2021, and completed pulmonary function tests (PFTs), serological tests, symptom-related questionnaires, and chest CT scans. Overall, 275 patients were included at a median of 82 days (IQR 64-111) post infection. 162 (59%) patients had diffusing capacity for carbon monoxide corrected for hemoglobin (DLCOc) below 80%, and 69 (25%) had bilateral chest abnormalities on CT scan. In multivariate analysis, anti-S levels were an independent predictor for DLCOc (β = - 0.14, p = 0.036). Anti-S levels were also associated with severe COVID-19 and older age, and correlated with anti-nucleocapsid (r = 0.30, p < 0.001) and antibodies to receptor binding domain (RBD, r = 0.37, p < 0.001). Other serological variables were not associated with clinical outcomes. In conclusion, symptomatic patients 3-months after COVID-19 had high respiratory symptomatic burden, in which anti-S levels were significantly associated with previous severe COVID-19 and DLCOc.
Keywords: Antibodies; Long-COVID; Monitoring; Pulmonary function tests; Respiratory; SARS-CoV-2; Serological variables.
. 2023 Jul 21.
doi: 10.1007/s10238-023-01139-5. Online ahead of print. Interactions and clinical implications of serological and respiratory variables 3 months after acute COVID-19
Ophir Freund[SUP] 1 [/SUP], Anna Breslavsky[SUP] 2 [/SUP], Sabrina Fried[SUP] 3 [/SUP], Rotem Givoli-Vilensky[SUP] 4 [/SUP], Shira Cohen-Rubin[SUP] 4 [/SUP], Nadav Zacks[SUP] 4 [/SUP], Eyal Kleinhendler[SUP] 3 [/SUP], Avraham Unterman[SUP] 3 [/SUP], Shir Frydman[SUP] 3 [/SUP], Ori Wand[SUP] 2 [/SUP], Natalya Bilenko[SUP] 4 5 [/SUP], Amir Bar-Shai[SUP] 3 [/SUP]
Affiliations
- PMID: 37479879
- DOI: 10.1007/s10238-023-01139-5
Medical follow-up of symptomatic patients after acute Coronavirus Disease 2019 (COVID-19) results in major burdens on patients and healthcare systems. The value of serological markers as part of this follow-up remains undetermined. We aimed to evaluate the clinical implications of serological markers for follow-up of acute COVID-19. For this purpose, we conducted an observational cohort study of patients 3 months after acute COVID-19. Participants visited a respiratory-clinic between October 2020 and March 2021, and completed pulmonary function tests (PFTs), serological tests, symptom-related questionnaires, and chest CT scans. Overall, 275 patients were included at a median of 82 days (IQR 64-111) post infection. 162 (59%) patients had diffusing capacity for carbon monoxide corrected for hemoglobin (DLCOc) below 80%, and 69 (25%) had bilateral chest abnormalities on CT scan. In multivariate analysis, anti-S levels were an independent predictor for DLCOc (β = - 0.14, p = 0.036). Anti-S levels were also associated with severe COVID-19 and older age, and correlated with anti-nucleocapsid (r = 0.30, p < 0.001) and antibodies to receptor binding domain (RBD, r = 0.37, p < 0.001). Other serological variables were not associated with clinical outcomes. In conclusion, symptomatic patients 3-months after COVID-19 had high respiratory symptomatic burden, in which anti-S levels were significantly associated with previous severe COVID-19 and DLCOc.
Keywords: Antibodies; Long-COVID; Monitoring; Pulmonary function tests; Respiratory; SARS-CoV-2; Serological variables.