tetano
Editor, Senior Moderator
Clin Exp Med
. 2024 Jan 20;24(1):12.
doi: 10.1007/s10238-023-01276-x. Humoral responses to wild type and ancient BA.1 SARS-CoV-2 variant after heterologous priming vaccination with ChAdOx1 nCoV-19 and BNT162b2 booster dose
Giuseppina Sanna[SUP] 1 [/SUP], Alessandra Marongiu[SUP] 2 [/SUP], Davide Firinu[SUP] 3 [/SUP], Cristina Piras[SUP] 4 [/SUP], Vanessa Palmas[SUP] 2 [/SUP], Massimiliano Galdiero[SUP] 5 [/SUP], Luigi Atzori[SUP] 4 [/SUP], Paola Caria[SUP] 2 [/SUP], Marcello Campagna[SUP] 6 [/SUP], Andrea Perra[SUP] 7 [/SUP], Giulia Costanzo[SUP] 6 [/SUP], Ferdinando Coghe[SUP] 8 [/SUP], Roberto Littera[SUP] 9 [/SUP], Luchino Chessa[SUP] 6 [/SUP], Aldo Manzin[SUP] 2 [/SUP]
Affiliations
Several countries have recommended a booster dose of Pfizer BNT162b2 vaccine for subjects under the age of 60, who have already received the first dose of ChAdOx1. This is due to several ChAdOx1 vaccine-associated adverse vascular events and thrombocytopenia. Neutralization assay and quantitative IgG anti-SARS-CoV-2 Spike antibody (anti-S-IgG) were conducted to investigate the long-term responses to vaccine treatment in a cohort of Sardinian participants, who have received heterologous Prime-Boost Vaccination via ChAdOx1 vector vaccine and a booster dose via BNT162b2. The obtained results were compared with those of a cohort of healthcare workers (HCW) who received homologous BNT162b2 (BNT/BNT/BNT) vaccination. One month (T2) and five months after the second and before the third dose (T3), anti-spike antibody or neutralizing titers in the subjects vaccinated with ChAdOx1-S/BNT162b2 were significantly higher than those who experienced the ChAdOx1-S/ChAdOx1-S or BNT162b2/BNT162b2 schedule. These results suggest that a ChAdOx1-S/BNT162b2 regimen provides a more robust antibody response than either of the homologous regimens. However, the anti-spike antibodies or neutralizing titers after the third injection (mRNA vaccine) of ChAdOx1-S as a second dose and BNT162b2 were not statistically different. Homologous and heterologous vaccination provided a strong antibody response. Neutralizing activities were also described against the Omicron BA.1 variant in a sub-group (40) representative of the three vaccination regimens among our cohort.
Keywords: Anti-S-IgG; BNT162b2 vaccine; Booster; COVID-19; ChAdOx1-S vaccine; Neutralizing antibodies; Omicron BA.1.
. 2024 Jan 20;24(1):12.
doi: 10.1007/s10238-023-01276-x. Humoral responses to wild type and ancient BA.1 SARS-CoV-2 variant after heterologous priming vaccination with ChAdOx1 nCoV-19 and BNT162b2 booster dose
Giuseppina Sanna[SUP] 1 [/SUP], Alessandra Marongiu[SUP] 2 [/SUP], Davide Firinu[SUP] 3 [/SUP], Cristina Piras[SUP] 4 [/SUP], Vanessa Palmas[SUP] 2 [/SUP], Massimiliano Galdiero[SUP] 5 [/SUP], Luigi Atzori[SUP] 4 [/SUP], Paola Caria[SUP] 2 [/SUP], Marcello Campagna[SUP] 6 [/SUP], Andrea Perra[SUP] 7 [/SUP], Giulia Costanzo[SUP] 6 [/SUP], Ferdinando Coghe[SUP] 8 [/SUP], Roberto Littera[SUP] 9 [/SUP], Luchino Chessa[SUP] 6 [/SUP], Aldo Manzin[SUP] 2 [/SUP]
Affiliations
- PMID: 38244064
- PMCID: PMC10799790
- DOI: 10.1007/s10238-023-01276-x
Several countries have recommended a booster dose of Pfizer BNT162b2 vaccine for subjects under the age of 60, who have already received the first dose of ChAdOx1. This is due to several ChAdOx1 vaccine-associated adverse vascular events and thrombocytopenia. Neutralization assay and quantitative IgG anti-SARS-CoV-2 Spike antibody (anti-S-IgG) were conducted to investigate the long-term responses to vaccine treatment in a cohort of Sardinian participants, who have received heterologous Prime-Boost Vaccination via ChAdOx1 vector vaccine and a booster dose via BNT162b2. The obtained results were compared with those of a cohort of healthcare workers (HCW) who received homologous BNT162b2 (BNT/BNT/BNT) vaccination. One month (T2) and five months after the second and before the third dose (T3), anti-spike antibody or neutralizing titers in the subjects vaccinated with ChAdOx1-S/BNT162b2 were significantly higher than those who experienced the ChAdOx1-S/ChAdOx1-S or BNT162b2/BNT162b2 schedule. These results suggest that a ChAdOx1-S/BNT162b2 regimen provides a more robust antibody response than either of the homologous regimens. However, the anti-spike antibodies or neutralizing titers after the third injection (mRNA vaccine) of ChAdOx1-S as a second dose and BNT162b2 were not statistically different. Homologous and heterologous vaccination provided a strong antibody response. Neutralizing activities were also described against the Omicron BA.1 variant in a sub-group (40) representative of the three vaccination regimens among our cohort.
Keywords: Anti-S-IgG; BNT162b2 vaccine; Booster; COVID-19; ChAdOx1-S vaccine; Neutralizing antibodies; Omicron BA.1.