tetano
Editor, Senior Moderator
Clin Drug Investig
. 2022 Aug 30.
doi: 10.1007/s40261-022-01195-x. Online ahead of print.
Protective Duration of ChAdOx1 and BNT162b2 Vaccines Against SARS-CoV-2 Infection
Amjad Alfaleh[SUP] 1 [/SUP], Abdullah Alkattan[SUP] 2 [/SUP], Abrar Alzaher[SUP] 3 [/SUP], Nashwa Radwan[SUP] 4 5 [/SUP], Nagla Mahmoud[SUP] 4 [/SUP], Alaa Alageel[SUP] 3 [/SUP], Dina Alhabib[SUP] 3 [/SUP], Eman Alsalameen[SUP] 6 [/SUP], Khlood Sagor[SUP] 3 [/SUP], Alhan Haji[SUP] 4 [/SUP], Amal Alfaifi[SUP] 4 [/SUP], Khaled Alabdulkareem[SUP] 4 7 [/SUP], Mona Ibrahim[SUP] 8 [/SUP]
Affiliations
Abstract
Background and objective: A limited number of studies have addressed the protective duration of coronavirus disease 2019 (COVID-19) vaccines following primary and booster doses in Saudi Arabia. Therefore, this study aimed to evaluate the protective duration of primary and booster doses of BNT162b2 and ChAdOx1 COVID-19 vaccine batches in Saudi Arabia.
Methods: A cross-sectional study was conducted from 1 January to 31 December, 2021. The study included 53,354 people infected with severe acute respiratory syndrome coronavirus-2 2 weeks or more after receiving at least a primary vaccination of either the ChAdOx1 or BNT162b2 vaccine.
Results: The total median protective duration of both primary COVID-19 vaccinations was 134 days. Heterologous primary vaccination (ChAdOx1 followed by BNT162b2) showed a significantly higher median protective duration of 142 days. The results show that the total median protective duration of the first booster doses of COVID-19 vaccines was 57 days. ChAdOx1 batch code C1 was found to have the most extended protective duration of 173 days (range 163-192 days).
Conclusions: The current study revealed that the median protective duration of ChAdOx1 and BNT162b2 COVID-19 primary vaccination regimens administered in Saudi Arabia in 2021 was 134 days and that heterologous primary vaccination (ChAdOx1→BNT162b2) exhibited a significantly higher protective duration than other vaccination regimens.
. 2022 Aug 30.
doi: 10.1007/s40261-022-01195-x. Online ahead of print.
Protective Duration of ChAdOx1 and BNT162b2 Vaccines Against SARS-CoV-2 Infection
Amjad Alfaleh[SUP] 1 [/SUP], Abdullah Alkattan[SUP] 2 [/SUP], Abrar Alzaher[SUP] 3 [/SUP], Nashwa Radwan[SUP] 4 5 [/SUP], Nagla Mahmoud[SUP] 4 [/SUP], Alaa Alageel[SUP] 3 [/SUP], Dina Alhabib[SUP] 3 [/SUP], Eman Alsalameen[SUP] 6 [/SUP], Khlood Sagor[SUP] 3 [/SUP], Alhan Haji[SUP] 4 [/SUP], Amal Alfaifi[SUP] 4 [/SUP], Khaled Alabdulkareem[SUP] 4 7 [/SUP], Mona Ibrahim[SUP] 8 [/SUP]
Affiliations
- PMID: 36040662
- DOI: 10.1007/s40261-022-01195-x
Abstract
Background and objective: A limited number of studies have addressed the protective duration of coronavirus disease 2019 (COVID-19) vaccines following primary and booster doses in Saudi Arabia. Therefore, this study aimed to evaluate the protective duration of primary and booster doses of BNT162b2 and ChAdOx1 COVID-19 vaccine batches in Saudi Arabia.
Methods: A cross-sectional study was conducted from 1 January to 31 December, 2021. The study included 53,354 people infected with severe acute respiratory syndrome coronavirus-2 2 weeks or more after receiving at least a primary vaccination of either the ChAdOx1 or BNT162b2 vaccine.
Results: The total median protective duration of both primary COVID-19 vaccinations was 134 days. Heterologous primary vaccination (ChAdOx1 followed by BNT162b2) showed a significantly higher median protective duration of 142 days. The results show that the total median protective duration of the first booster doses of COVID-19 vaccines was 57 days. ChAdOx1 batch code C1 was found to have the most extended protective duration of 173 days (range 163-192 days).
Conclusions: The current study revealed that the median protective duration of ChAdOx1 and BNT162b2 COVID-19 primary vaccination regimens administered in Saudi Arabia in 2021 was 134 days and that heterologous primary vaccination (ChAdOx1→BNT162b2) exhibited a significantly higher protective duration than other vaccination regimens.