tetano
Editor, Senior Moderator
Clin Drug Investig
. 2022 Oct 23.
doi: 10.1007/s40261-022-01216-9. Online ahead of print.
COVID-19 mRNA Vaccines: A Retrospective Observational Pharmacovigilance Study
Francesco Ferrara[SUP] 1 [/SUP], Carolina Mancaniello[SUP] 2 [/SUP], Alessia Varriale[SUP] 2 [/SUP], Sarah Sorrentino[SUP] 2 [/SUP], Andrea Zovi[SUP] 3 [/SUP], Eduardo Nava[SUP] 2 [/SUP], Ugo Trama[SUP] 4 [/SUP], Mariarosaria Boccellino[SUP] 5 [/SUP], Antonio Vitiello[SUP] 6 [/SUP]
Affiliations
Abstract
Background and objective: Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus has caused millions of deaths worldwide. The mRNA vaccines prevented the figure from being more severe. The objective of this retrospective study is to evaluate the safety of COVID-19 vaccines by analyzing the adverse events following immunization (AEFIs).
Methods: A retrospective observational pharmacovigilance study was conducted, based on the collection of reports of suspected AEFIs reported between 1 January 2021 and 31 December 2021 at the Naples 3 local health authority. AEFIs were stratified and described according to mRNA vaccine, demographics, clinical status, description of AEFI, and degree of severity. In 2021, local health authority Asl Naples 3 South received 1164 reports of suspected adverse events that occurred following the administration of mRNA vaccines.
Results: During the reporting period, 746 reports were related to the Comirnaty vaccine (64.1%), 281 to the Vaxzevria vaccine (24.1%), 107 to the Spikevax vaccine (9.2%), and 30 to the Jcovden vaccine (2.6%); 89.3% of the reports were classified as not serious (N = 1039 reports), the remaining 10.7% as serious (N = 125 reports).
Conclusions: This retrospective pharmacovigilance study demonstrates that COVID-19 mRNA vaccines are safe in all population groups.
. 2022 Oct 23.
doi: 10.1007/s40261-022-01216-9. Online ahead of print.
COVID-19 mRNA Vaccines: A Retrospective Observational Pharmacovigilance Study
Francesco Ferrara[SUP] 1 [/SUP], Carolina Mancaniello[SUP] 2 [/SUP], Alessia Varriale[SUP] 2 [/SUP], Sarah Sorrentino[SUP] 2 [/SUP], Andrea Zovi[SUP] 3 [/SUP], Eduardo Nava[SUP] 2 [/SUP], Ugo Trama[SUP] 4 [/SUP], Mariarosaria Boccellino[SUP] 5 [/SUP], Antonio Vitiello[SUP] 6 [/SUP]
Affiliations
- PMID: 36274082
- DOI: 10.1007/s40261-022-01216-9
Abstract
Background and objective: Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus has caused millions of deaths worldwide. The mRNA vaccines prevented the figure from being more severe. The objective of this retrospective study is to evaluate the safety of COVID-19 vaccines by analyzing the adverse events following immunization (AEFIs).
Methods: A retrospective observational pharmacovigilance study was conducted, based on the collection of reports of suspected AEFIs reported between 1 January 2021 and 31 December 2021 at the Naples 3 local health authority. AEFIs were stratified and described according to mRNA vaccine, demographics, clinical status, description of AEFI, and degree of severity. In 2021, local health authority Asl Naples 3 South received 1164 reports of suspected adverse events that occurred following the administration of mRNA vaccines.
Results: During the reporting period, 746 reports were related to the Comirnaty vaccine (64.1%), 281 to the Vaxzevria vaccine (24.1%), 107 to the Spikevax vaccine (9.2%), and 30 to the Jcovden vaccine (2.6%); 89.3% of the reports were classified as not serious (N = 1039 reports), the remaining 10.7% as serious (N = 125 reports).
Conclusions: This retrospective pharmacovigilance study demonstrates that COVID-19 mRNA vaccines are safe in all population groups.