tetano
Editor, Senior Moderator
Clin Chem Lab Med
. 2020 Oct 7;/j/cclm.ahead-of-print/cclm-2020-1414/cclm-2020-1414.xml.
doi: 10.1515/cclm-2020-1414. Online ahead of print.
IFCC interim guidelines on biochemical/hematological monitoring of COVID-19 patients
Simon Thompson[SUP] 1 [/SUP], Mary Kathryn Bohn[SUP] 2 3 [/SUP], Nicasio Mancini[SUP] 4 [/SUP], Tze Ping Loh[SUP] 5 [/SUP], Cheng-Bin Wang[SUP] 6 [/SUP], Matthias Grimmler[SUP] 7 [/SUP], Kwok-Yung Yuen[SUP] 8 [/SUP], Robert Mueller[SUP] 9 [/SUP], David Koch[SUP] 10 [/SUP], Sunil Sethi[SUP] 5 [/SUP], William D Rawlinson[SUP] 11 [/SUP], Massimo Clementi[SUP] 4 [/SUP], Rajiv Erasmus[SUP] 12 [/SUP], Marc Leportier[SUP] 13 [/SUP], Gye Cheol Kwon[SUP] 14 [/SUP], Mar?a Elizabeth Menezes[SUP] 15 [/SUP], Maria-Magdalena Patru[SUP] 16 [/SUP], Maurizio Gramegna[SUP] 17 [/SUP], Krishna Singh[SUP] 18 [/SUP], Osama Najjar[SUP] 19 [/SUP], Maurizio Ferrari[SUP] 4 [/SUP], Giuseppe Lippi[SUP] 20 [/SUP], Khosrow Adeli[SUP] 2 3 [/SUP], Andrea Horvath[SUP] 1 1 21 [/SUP]
Affiliations
Abstract
Routine biochemical and hematological tests have been reported to be useful in the stratification and prognostication of pediatric and adult patients with diagnosed coronavirus disease (COVID-19), correlating with poor outcomes such as the need for mechanical ventilation or intensive care, progression to multisystem organ failure, and/or death. While these tests are already well established in most clinical laboratories, there is still debate regarding their clinical value in the management of COVID-19, particularly in pediatrics, as well as the value of composite clinical risk scores in COVID-19 prognostication. This document by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Task Force on COVID-19 provides interim guidance on: (A) clinical indications for testing, (B) recommendations for test selection and interpretation, (C) considerations in test interpretation, and (D) current limitations of biochemical/hematological monitoring of COVID-19 patients. These evidence-based recommendations will provide practical guidance to clinical laboratories worldwide, underscoring the contribution of biochemical and hematological testing to our collective pandemic response.
Keywords: COVID-19; SARS-CoV-2; biochemistry; hematology.
. 2020 Oct 7;/j/cclm.ahead-of-print/cclm-2020-1414/cclm-2020-1414.xml.
doi: 10.1515/cclm-2020-1414. Online ahead of print.
IFCC interim guidelines on biochemical/hematological monitoring of COVID-19 patients
Simon Thompson[SUP] 1 [/SUP], Mary Kathryn Bohn[SUP] 2 3 [/SUP], Nicasio Mancini[SUP] 4 [/SUP], Tze Ping Loh[SUP] 5 [/SUP], Cheng-Bin Wang[SUP] 6 [/SUP], Matthias Grimmler[SUP] 7 [/SUP], Kwok-Yung Yuen[SUP] 8 [/SUP], Robert Mueller[SUP] 9 [/SUP], David Koch[SUP] 10 [/SUP], Sunil Sethi[SUP] 5 [/SUP], William D Rawlinson[SUP] 11 [/SUP], Massimo Clementi[SUP] 4 [/SUP], Rajiv Erasmus[SUP] 12 [/SUP], Marc Leportier[SUP] 13 [/SUP], Gye Cheol Kwon[SUP] 14 [/SUP], Mar?a Elizabeth Menezes[SUP] 15 [/SUP], Maria-Magdalena Patru[SUP] 16 [/SUP], Maurizio Gramegna[SUP] 17 [/SUP], Krishna Singh[SUP] 18 [/SUP], Osama Najjar[SUP] 19 [/SUP], Maurizio Ferrari[SUP] 4 [/SUP], Giuseppe Lippi[SUP] 20 [/SUP], Khosrow Adeli[SUP] 2 3 [/SUP], Andrea Horvath[SUP] 1 1 21 [/SUP]
Affiliations
- PMID: 33027044
- DOI: 10.1515/cclm-2020-1414
Abstract
Routine biochemical and hematological tests have been reported to be useful in the stratification and prognostication of pediatric and adult patients with diagnosed coronavirus disease (COVID-19), correlating with poor outcomes such as the need for mechanical ventilation or intensive care, progression to multisystem organ failure, and/or death. While these tests are already well established in most clinical laboratories, there is still debate regarding their clinical value in the management of COVID-19, particularly in pediatrics, as well as the value of composite clinical risk scores in COVID-19 prognostication. This document by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Task Force on COVID-19 provides interim guidance on: (A) clinical indications for testing, (B) recommendations for test selection and interpretation, (C) considerations in test interpretation, and (D) current limitations of biochemical/hematological monitoring of COVID-19 patients. These evidence-based recommendations will provide practical guidance to clinical laboratories worldwide, underscoring the contribution of biochemical and hematological testing to our collective pandemic response.
Keywords: COVID-19; SARS-CoV-2; biochemistry; hematology.