tetano
Editor, Senior Moderator
Clin Biochem
. 2022 Mar 17;S0009-9120(22)00076-5.
doi: 10.1016/j.clinbiochem.2022.03.002. Online ahead of print.
The Importance of Neopterin in COVID-19: the prognostic value and relation with the disease severity
Yousef Rasmi[SUP] 1 [/SUP], Nadia Heidari[SUP] 2 [/SUP], Kevser Kübra Kırboğa[SUP] 3 [/SUP], Shima Hatamkhani[SUP] 4 [/SUP], Burcu Tekin[SUP] 5 [/SUP], Shahryar Alipour[SUP] 6 [/SUP], Roya Naderi[SUP] 7 [/SUP], Yeghaneh Farnamian[SUP] 8 [/SUP], Ilknur Akca[SUP] 9 [/SUP]
Affiliations
Abstract
Coronavirus Disease 2019 [COVID-19], caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], has rapidly evolved into a global health emergency. Neopterin [NPT], produced by macrophages when stimulated with interferon [IFN-]gamma, is an essential cytokine in the antiviral immune response. NPT has been used as a marker for the early assessment of disease severity in different diseases. The leading cause of NPT production is the pro-inflammatory cytokine IFN-. Macrophage activation has also been revealed to be linked with disease severity in SARS-CoV-2 patients. We demonstrate the importance of NPT in the pathogenesis of SARS-CoV-2 and suggest that targeting NPT in SARS-CoV-2 infection may be critical in the early prediction of disease progression and provision of timely management of infected individuals.
Keywords: COVID-19; Neopterin; SARS CoV-2; prognosis.
. 2022 Mar 17;S0009-9120(22)00076-5.
doi: 10.1016/j.clinbiochem.2022.03.002. Online ahead of print.
The Importance of Neopterin in COVID-19: the prognostic value and relation with the disease severity
Yousef Rasmi[SUP] 1 [/SUP], Nadia Heidari[SUP] 2 [/SUP], Kevser Kübra Kırboğa[SUP] 3 [/SUP], Shima Hatamkhani[SUP] 4 [/SUP], Burcu Tekin[SUP] 5 [/SUP], Shahryar Alipour[SUP] 6 [/SUP], Roya Naderi[SUP] 7 [/SUP], Yeghaneh Farnamian[SUP] 8 [/SUP], Ilknur Akca[SUP] 9 [/SUP]
Affiliations
- PMID: 35307400
- DOI: 10.1016/j.clinbiochem.2022.03.002
Abstract
Coronavirus Disease 2019 [COVID-19], caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], has rapidly evolved into a global health emergency. Neopterin [NPT], produced by macrophages when stimulated with interferon [IFN-]gamma, is an essential cytokine in the antiviral immune response. NPT has been used as a marker for the early assessment of disease severity in different diseases. The leading cause of NPT production is the pro-inflammatory cytokine IFN-. Macrophage activation has also been revealed to be linked with disease severity in SARS-CoV-2 patients. We demonstrate the importance of NPT in the pathogenesis of SARS-CoV-2 and suggest that targeting NPT in SARS-CoV-2 infection may be critical in the early prediction of disease progression and provision of timely management of infected individuals.
Keywords: COVID-19; Neopterin; SARS CoV-2; prognosis.