Gert van der Hoek
In Memoriam - Editor, Senior Moderator
8-FEB-2016
New research from Brigham and Women's Hospital finds that circadian misalignment increases blood pressure and inflammatory markers
BOSTON, MA - Shift workers frequently undergo circadian misalignment, disruption of the "body clock," caused by inverted wake and sleep cycles. Although shift work, which requires workers to be awake when the brain's circadian clock is expecting sleep, is known to be a risk factor for hypertension, inflammation and cardiovascular disease, little is known about the specific impact of circadian misalignment on cardiovascular disease risk in humans.
New research from Brigham and Women's Hospital (BWH) published in the Proceedings of the National Academy of Sciences on February 8, 2016, may help explain why shift work increases the risk for cardiovascular disease. The study finds that short-term circadian misalignment, resulting from a rapid 12-hour inversion of the sleep/wake and fasting/feeding cycle that is typical in shift workers, leads to adverse cardiovascular and inflammatory consequences in healthy adults.
"We were able to determine, under highly controlled laboratory conditions, the independent impact of circadian misalignment on cardiovascular disease risk factors -blood pressure and inflammatory markers," said Frank A.J.L. Scheer, PhD, neuroscientist in the Division of Sleep and Circadian Disorders at BWH, and the senior author of the study. "Our findings provide evidence for circadian misalignment as an underlying mechanism to explain why shift work is a risk factor for elevated blood pressure, hypertension, inflammation and cardiovascular disease."
Researchers measured blood pressure and inflammatory markers, which are strongly predictive of cardiovascular disease risk, and compared circadian misalignment with circadian alignment in 14 healthy subjects during two eight-day stays in the BWH sleep laboratory. One stay included circadian misalignment, and the other maintained circadian alignment. Controlling for other contributing factors, such as work stressors, dietary habits, physical activity, as well as family, financial, genetic, health and social factors, researchers found that circadian misalignment:
New research from Brigham and Women's Hospital finds that circadian misalignment increases blood pressure and inflammatory markers
BOSTON, MA - Shift workers frequently undergo circadian misalignment, disruption of the "body clock," caused by inverted wake and sleep cycles. Although shift work, which requires workers to be awake when the brain's circadian clock is expecting sleep, is known to be a risk factor for hypertension, inflammation and cardiovascular disease, little is known about the specific impact of circadian misalignment on cardiovascular disease risk in humans.
New research from Brigham and Women's Hospital (BWH) published in the Proceedings of the National Academy of Sciences on February 8, 2016, may help explain why shift work increases the risk for cardiovascular disease. The study finds that short-term circadian misalignment, resulting from a rapid 12-hour inversion of the sleep/wake and fasting/feeding cycle that is typical in shift workers, leads to adverse cardiovascular and inflammatory consequences in healthy adults.
"We were able to determine, under highly controlled laboratory conditions, the independent impact of circadian misalignment on cardiovascular disease risk factors -blood pressure and inflammatory markers," said Frank A.J.L. Scheer, PhD, neuroscientist in the Division of Sleep and Circadian Disorders at BWH, and the senior author of the study. "Our findings provide evidence for circadian misalignment as an underlying mechanism to explain why shift work is a risk factor for elevated blood pressure, hypertension, inflammation and cardiovascular disease."
Researchers measured blood pressure and inflammatory markers, which are strongly predictive of cardiovascular disease risk, and compared circadian misalignment with circadian alignment in 14 healthy subjects during two eight-day stays in the BWH sleep laboratory. One stay included circadian misalignment, and the other maintained circadian alignment. Controlling for other contributing factors, such as work stressors, dietary habits, physical activity, as well as family, financial, genetic, health and social factors, researchers found that circadian misalignment:
- Increased 24-hour systolic blood pressure (SBP) and diastolic blood pressure (DBP)
- Reduced blood pressure dipping, usually associated with sleep
- Decreased measures of autonomic nervous system activity (controlling bodily functions such as blood pressure)
- Increased inflammatory markers