tetano
Editor, Senior Moderator
Circ J
. 2021 Apr 29.
doi: 10.1253/circj.CJ-21-0160. Online ahead of print.
Clinical and Biomarker Profiles and Prognosis of Elderly Patients With Coronavirus Disease 2019 (COVID-19) With Cardiovascular Diseases and/or Risk Factors
Shingo Matsumoto[SUP] 1 [/SUP], Shunsuke Kuroda[SUP] 2 3 [/SUP], Takahide Sano[SUP] 1 4 [/SUP], Takeshi Kitai[SUP] 5 [/SUP], Taishi Yonetsu[SUP] 6 [/SUP], Shun Kohsaka[SUP] 7 [/SUP], Sho Torii[SUP] 8 [/SUP], Takuya Kishi[SUP] 9 [/SUP], Issei Komuro[SUP] 10 [/SUP], Ken-Ichi Hirata[SUP] 11 [/SUP], Koichi Node[SUP] 12 [/SUP], Yuya Matsue[SUP] 13 14 [/SUP]
Affiliations
Abstract
Background: This study investigated the effects of age on the outcomes of coronavirus disease 2019 (COVID-19) and on cardiac biomarker profiles, especially in patients with cardiovascular diseases and/or risk factors (CVDRF).Methods and Results:A nationwide multicenter retrospective study included 1,518 patients with COVID-19. Of these patients, 693 with underlying CVDRF were analyzed; patients were divided into age groups (<55, 55-64, 65-79, and ?80 years) and in-hospital mortality and age-specific clinical and cardiac biomarker profiles on admission evaluated. Overall, the mean age of patients was 68 years, 449 (64.8%) were male, and 693 (45.7%) had underlying CVDRF. Elderly (?80 years) patients had a significantly higher risk of in-hospital mortality regardless of concomitant CVDRF than younger patients (P<0.001). Typical characteristics related to COVID-19, including symptoms and abnormal findings on baseline chest X-ray and computed tomography scans, were significantly less prevalent in the elderly group than in the younger groups. However, a significantly (P<0.001) higher proportion of elderly patients were positive for cardiac troponin (cTn), and B-type natriuretic peptide (BNP) and N-terminal pro BNP (NT-proBNP) levels on admission were significantly higher among elderly than younger patients (P<0.001 and P=0.001, respectively).
Conclusions: Elderly patients with COVID-19 had a higher risk of mortality during the hospital course, regardless of their history of CVDRF, were more likely to be cTn positive, and had significantly higher BNP/NT-proBNP levels than younger patients.
Keywords: Age; B-type natriuretic peptide; Cardiac troponin; Cardiovascular disease; Coronavirus disease 2019 (COVID-19).
. 2021 Apr 29.
doi: 10.1253/circj.CJ-21-0160. Online ahead of print.
Clinical and Biomarker Profiles and Prognosis of Elderly Patients With Coronavirus Disease 2019 (COVID-19) With Cardiovascular Diseases and/or Risk Factors
Shingo Matsumoto[SUP] 1 [/SUP], Shunsuke Kuroda[SUP] 2 3 [/SUP], Takahide Sano[SUP] 1 4 [/SUP], Takeshi Kitai[SUP] 5 [/SUP], Taishi Yonetsu[SUP] 6 [/SUP], Shun Kohsaka[SUP] 7 [/SUP], Sho Torii[SUP] 8 [/SUP], Takuya Kishi[SUP] 9 [/SUP], Issei Komuro[SUP] 10 [/SUP], Ken-Ichi Hirata[SUP] 11 [/SUP], Koichi Node[SUP] 12 [/SUP], Yuya Matsue[SUP] 13 14 [/SUP]
Affiliations
- PMID: 33952834
- DOI: 10.1253/circj.CJ-21-0160
Abstract
Background: This study investigated the effects of age on the outcomes of coronavirus disease 2019 (COVID-19) and on cardiac biomarker profiles, especially in patients with cardiovascular diseases and/or risk factors (CVDRF).Methods and Results:A nationwide multicenter retrospective study included 1,518 patients with COVID-19. Of these patients, 693 with underlying CVDRF were analyzed; patients were divided into age groups (<55, 55-64, 65-79, and ?80 years) and in-hospital mortality and age-specific clinical and cardiac biomarker profiles on admission evaluated. Overall, the mean age of patients was 68 years, 449 (64.8%) were male, and 693 (45.7%) had underlying CVDRF. Elderly (?80 years) patients had a significantly higher risk of in-hospital mortality regardless of concomitant CVDRF than younger patients (P<0.001). Typical characteristics related to COVID-19, including symptoms and abnormal findings on baseline chest X-ray and computed tomography scans, were significantly less prevalent in the elderly group than in the younger groups. However, a significantly (P<0.001) higher proportion of elderly patients were positive for cardiac troponin (cTn), and B-type natriuretic peptide (BNP) and N-terminal pro BNP (NT-proBNP) levels on admission were significantly higher among elderly than younger patients (P<0.001 and P=0.001, respectively).
Conclusions: Elderly patients with COVID-19 had a higher risk of mortality during the hospital course, regardless of their history of CVDRF, were more likely to be cTn positive, and had significantly higher BNP/NT-proBNP levels than younger patients.
Keywords: Age; B-type natriuretic peptide; Cardiac troponin; Cardiovascular disease; Coronavirus disease 2019 (COVID-19).